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Multigenic architecture

Multigenic architecture of piperaquine resistance trait in Plasmodium falciparum

January 15, 2020 - 08:59 -- Open Access
Silva M, Calçada C, Teixeira M, Veiga MI, Ferreira PE
Lancet Infect Dis. 2020 Jan; 20(1):26-27

William L Hamilton and colleagues1 and Rob W van der Pluijm and colleagues2 described the genomic evolution of Plasmodium falciparum malaria and the spread of resistance in this species to dihydroartemisinin–piperaquine in Southeast Asia. Resistance in the region has been associated with crt polymorphisms, 1, 2, 3 copy number variations in plasmepsins, 1, 2, 3, 4, 5 and mdr1 genes.4, 5

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