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Citrus Species

NOT Open Access | Multiple-targets Directed Screening of Flavonoid Compounds from Citrus Species to find out Antimalarial Lead with Predicted Mode of Action: An In Silico and Whole Cell-based In vitro Approach

January 15, 2020 - 08:03 -- NOT Open Access
Author(s): 
Gogoi N, Chetia D, Gogoi B, Das A
Reference: 
Current Computer-Aided Drug Design, 2019 Dec 25

In this study, 44 flavonoids found mainly in the fruit juice of Citrus species having traditional use in malaria-associated fever were selected for in silico multiple-target directed screening against three vital targets of the parasite namely dihydrooroate dehydrogenase (PfDHODH), dihydrofolate reductase thymidine synthase (PfDHFR-TS) and plasma membrane P-type cation translocating ATPase (PfATP4) to find out new lead molecule(s).

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