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NOT Open Access | Targeting metacaspase-3 from Plasmodium falciparum towards antimalarial therapy: A combined approach of in-silico and in-vitro investigation

January 14, 2020 - 16:46 -- NOT Open Access
Kumar B, Mohammad T, Amaduddin, Hussain A, Islam A, Ahmad F, Alajmi MF, Singh S, Pandey KC, Hassan MI, Abid M
Journal of Biomolecular Structure and Dynamics, 2020 Jan 13:1-10

Malaria is a global challenge, and its infection is propagated through Plasmodium falciparum, an obligate human parasite. The genome of P. falciparum encodes many proteases that play significant roles in their survival and pathogenesis thus being considered as attractive drug targets. P. falciparum metacaspase-3 (PfMCA3) is one such protease and a validated drug target to control malarial infection.

NOT Open Access | In-silico profiling and structural insights into the impact of nSNPs in the P. falciparum acetyl-CoA transporter gene to understand the mechanism of drug resistance in malaria

January 14, 2020 - 16:24 -- NOT Open Access
Sardar R, Katyal N, Ahamad S, Jade DD, Ali S, Gupta D
Journal of Biomolecular Structure and Dynamics, 2020 Jan 6:1-23

The continuous emergence of resistance to the available drugs poses major constraints in the development of effective therapeutics against Malaria. The Malaria drug resistance has been attributed to be the manifestation of numerous factors. For example, mutations in the parasite transporter protein acetyl-CoA transporter (Pfact) can remarkably affect its uptake affinity for a drug molecule against malaria, and hence enhance its susceptibility to resistance.

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