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lactate dehydrogenase

Ultra-sensitive RDT performance and antigen dynamics in a high-transmission Plasmodium falciparum setting in Mali

September 5, 2020 - 15:03 -- Open Access
Emily N. Reichert, Jen C. C. Hume, Hannah C. Slater, et al.
Malaria Journal 2020 19:323, 3 September 2020

The recent expansion of tools designed to accurately quantify malaria parasite-produced antigens has enabled us to evaluate the performance of rapid diagnostic tests (RDTs) as a function of the antigens they detect—typically histidine rich protein 2 (HRP2) or lactate dehydrogenase (LDH).

NOT Open Access | Capture and Detection of Plasmodium vivax Lactate Dehydrogenase in a Bead-Based Multiplex Immunoassay

March 9, 2020 - 14:30 -- NOT Open Access
Rogier E, Nace D, Ljolje D, Lucchi NW, Udhayakumar V, Aidoo M
Am J Trop Med Hyg. 2020 Mar 2

Laboratory detection of malaria antigens has proved valuable for research and epidemiological purposes. We recently developed a bead-based multiplex antigen assay for pan-Plasmodium and Plasmodium falciparum targets. Here, we report integration of a Plasmodium vivax–specific target to this multiplex panel: P. vivax lactate dehydrogenase (PvLDH).

NOT Open Access | Identification of a novel binding mechanism of Quinoline based molecules with lactate dehydrogenase of Plasmodium falciparum

January 14, 2020 - 16:22 -- NOT Open Access
Singh R, Bhardwaj V, Purohit R
Journal of Biomolecular Structure and Dynamics, 2020 Jan 6:1-15

The deadliest disease caused by the Plasmodium species is malaria. Among other species, the infection caused by Plasmodium falciparum (Pf) is life-threatening.The biological function and three dimensional structure of PfLDH and human LDH are very similar. Any treatment aiming to inhibit the PfLDH can also affect the activity of human LDH. This study aims to identify molecules that show high selectivity for PfLDH without having a profound effect on the activity of human LDH. In this study, 30 in-house synthesized Quinolines based molecules were docked with both PfLDH and human LDH.

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