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Quinoline based molecules

NOT Open Access | Identification of a novel binding mechanism of Quinoline based molecules with lactate dehydrogenase of Plasmodium falciparum

January 14, 2020 - 16:22 -- NOT Open Access
Singh R, Bhardwaj V, Purohit R
Journal of Biomolecular Structure and Dynamics, 2020 Jan 6:1-15

The deadliest disease caused by the Plasmodium species is malaria. Among other species, the infection caused by Plasmodium falciparum (Pf) is life-threatening.The biological function and three dimensional structure of PfLDH and human LDH are very similar. Any treatment aiming to inhibit the PfLDH can also affect the activity of human LDH. This study aims to identify molecules that show high selectivity for PfLDH without having a profound effect on the activity of human LDH. In this study, 30 in-house synthesized Quinolines based molecules were docked with both PfLDH and human LDH.

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