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NOT Open Access | Hydroxylamine and Carboxymethoxylamine Can Inhibit Toxoplasma gondii Growth Through an Aspartate aminotransferase-independent Pathway

January 14, 2020 - 16:05 -- NOT Open Access
Li J, Guo H, Galon EM, Gao Y, Lee SH, Liu M, Li Y, Ji S, Jia H, Xuan X
Antimicrob Agents Chemother. 2020 Jan 6. pii: AAC.01889-19

Toxoplasma gondii is an obligate intracellular protozoan parasite and a successful parasitic pathogen in diverse organisms and host cell types. Hydroxylamine (HYD) and carboxymethoxylamine (CAR) have been reported as inhibitors of aspartate aminotransferases (AATs), and interferes with the proliferation in Plasmodium falciparum. Therefore, AATs are suggested as drug targets against Plasmodium. T. gondii genome encodes only one predicted AAT in both T. gondii type I RH and type II PLK strains.

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