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NK cells

Protective Vaccination Reshapes Hepatic Response to Blood-Stage Malaria of Genes Preferentially Expressed by NK Cells

November 19, 2020 - 13:13 -- Open Access
Araúzo-Bravo MJ, Delic D, Gerovska D, Wunderlich F
Vaccines (Basel). 2020 Nov 13;8(4):E677

The role of natural killer (NK) cells in the liver as first-line post infectionem (p.i.) effectors against blood-stage malaria and their responsiveness to protective vaccination is poorly understood. Here, we investigate the effect of vaccination on NK cell-associated genes induced in the liver by blood-stage malaria of Plasmodium chabaudi. Female Balb/c mice were vaccinated at weeks 3 and 1 before being infected with 106P. chabaudi-parasitized erythrocytes.

NOT Open Access | PD-1 expression on NK cells in malaria-exposed individuals is associated with diminished natural cytotoxicity and enhanced antibody dependent cellular cytotoxicity

January 14, 2020 - 12:21 -- NOT Open Access
Moebius J, Guha R, Peterson M, Abdi K, Skinner J, Li S, Arora G, Traore B, Rajagopalan S, Long EO, Crompton PD
Infect Immun. 2020 Jan 6. pii: IAI.00711-19

Natural killer (NK) cells are key effector cells of innate resistance capable of destroying tumors and virus-infected cells through cytotoxicity and rapid cytokine production. The control of NK cell responses is complex and only partially understood. PD-1 is an inhibitory receptor that regulates T cell function, but a role for PD-1 in regulating NK cell function is only beginning to emerge. Here we investigated PD-1 expression on NK cells in children and adults in Mali in a longitudinal analysis before, during and after infection with Plasmodium falciparum malaria.

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