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NK cells

Protective Vaccination Reshapes Hepatic Response to Blood-Stage Malaria of Genes Preferentially Expressed by NK Cells

November 19, 2020 - 13:13 -- Open Access
Author(s): 
Araúzo-Bravo MJ, Delic D, Gerovska D, Wunderlich F
Reference: 
Vaccines (Basel). 2020 Nov 13;8(4):E677

The role of natural killer (NK) cells in the liver as first-line post infectionem (p.i.) effectors against blood-stage malaria and their responsiveness to protective vaccination is poorly understood. Here, we investigate the effect of vaccination on NK cell-associated genes induced in the liver by blood-stage malaria of Plasmodium chabaudi. Female Balb/c mice were vaccinated at weeks 3 and 1 before being infected with 106P. chabaudi-parasitized erythrocytes.

NOT Open Access | PD-1 expression on NK cells in malaria-exposed individuals is associated with diminished natural cytotoxicity and enhanced antibody dependent cellular cytotoxicity

January 14, 2020 - 12:21 -- NOT Open Access
Author(s): 
Moebius J, Guha R, Peterson M, Abdi K, Skinner J, Li S, Arora G, Traore B, Rajagopalan S, Long EO, Crompton PD
Reference: 
Infect Immun. 2020 Jan 6. pii: IAI.00711-19

Natural killer (NK) cells are key effector cells of innate resistance capable of destroying tumors and virus-infected cells through cytotoxicity and rapid cytokine production. The control of NK cell responses is complex and only partially understood. PD-1 is an inhibitory receptor that regulates T cell function, but a role for PD-1 in regulating NK cell function is only beginning to emerge. Here we investigated PD-1 expression on NK cells in children and adults in Mali in a longitudinal analysis before, during and after infection with Plasmodium falciparum malaria.

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