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chalcone derivatives

Ultrastructural alterations in Plasmodium falciparum induced by chalcone derivatives

June 17, 2020 - 12:54 -- Open Access
Sinha S, Radotra BD, Medhi B, Batovska DI, Markova N, Sehgal R
BMC Res Notes. 2020 Jun 15; 13(1):290

Chalcones (1, 3-diaryl-2-propen-1-ones) and their derivatives are widely explored from the past decade for its antimalarial activity. To elucidate their mechanism of action on the malaria parasite, the ultrastructural changes with the action of these derivatives in different organelles of the parasite were studied in vitro. Infected RBCs [CQ sensitive (MRC-2) and CQ resistant (RKL-9) Plasmodium strain] were treated with three chalcone derivatives 1, 2 and 3 and standard drugs, i.e., CQ and artemisinin at twice their respective IC50 values for 24 h and then harvested, washed, fixed, embedded and stained to visualize ultra-structure changes before and after intervention of treatment under in vitro condition through transmission electron microscope.

NOT Open Access | Ex vivo efficacy of selective chalcone derivatives on reference strains and field isolates of Plasmodium falciparum

January 14, 2020 - 12:12 -- NOT Open Access
Dable MT, Tano KD, Ouattara M, Silue KD, Menan EIH, Yavo W
Pathogens and Global Health, 2020 Jan 7:1-5

The extension of Plasmodium falciparum resistance to existing antimalarial drugs is worrying. Faced with this problem, the search for new and effective molecules is necessary. In this context, six chalcone derivatives (B1, B11, B14, B17, SCA02 and SCA03) were tested on field isolates and then reference strains to evaluate their antiplasmodial activity by using the Rieckmann semi-microtest, recommended by WHO, for in vitro and ex vivo activity tests.

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