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pyrethroid-resistant

Efficacy of broflanilide (VECTRON T500), a new meta-diamide insecticide, for indoor residual spraying against pyrethroid-resistant malaria vectors

April 13, 2021 - 13:31 -- Open Access
Author(s): 
Ngufor C, Govoetchan R, Fongnikin A, Vigninou E, Syme T, Akogbeto M, Rowland M
Reference: 
Sci Rep. 2021 Apr 12;11(1):7976

The rotational use of insecticides with different modes of action for indoor residual spraying (IRS) is recommended for improving malaria vector control and managing insecticide resistance. Insecticides with new chemistries are urgently needed. Broflanilide is a newly discovered insecticide under consideration. We investigated the efficacy of a wettable powder (WP) formulation of broflanilide (VECTRON T500) for IRS on mud and cement wall substrates in laboratory and experimental hut studies against pyrethroid-resistant malaria vectors in Benin, in comparison with pirimiphos-methyl CS (Actellic 300CS).

Efficacy of indoor residual spraying with broflanilide (TENEBENAL), a novel meta-diamide insecticide, against pyrethroid-resistant anopheline vectors in northern Tanzania: An experimental hut trial

March 9, 2021 - 15:59 -- Open Access
Author(s): 
Snetselaar J, Rowland MW, Manunda BJ, Kisengwa EM, Small GJ, Malone DJ, Mosha FW, Kirby MJ
Reference: 
PLoS One. 2021 Mar 3;16(3):e0248026

Novel chemistry for vector control is urgently needed to counter insecticide resistance in mosquitoes. Here a new meta-diamide insecticide, broflanilide (TENEBENALTM), was evaluated in East African experimental huts in Moshi, northern Tanzania. Two consecutive experimental hut trials with broflanilide 50WP were conducted; the first evaluating the efficacy of three concentrations, 50 mg/m2, 100 mg/m2, and 200 mg/m2 using a prototype formulation, and the second trial evaluating an improved formulation.

Assessing the efficacy of two dual-active ingredients long-lasting insecticidal nets for the control of malaria transmitted by pyrethroid-resistant vectors in Benin: study protocol for a three-arm, single-blinded, parallel, cluster-randomized controlled t

February 23, 2021 - 13:08 -- Open Access
Author(s): 
Accrombessi M, Cook J, Protopopoff N, et al.
Reference: 
BMC Infect Dis. 2021 Feb 19;21(1):194

Long-lasting insecticidal nets (LLINs) are currently the primary method of malaria control in sub-Saharan Africa and have contributed to a significant reduction in malaria burden over the past 15 years. However, this progress is threatened by the wide-scale selection of insecticide-resistant malaria vectors. It is, therefore, important to accelerate the generation of evidence for new classes of LLINs.

New insecticide screening platforms indicate that Mitochondrial Complex I inhibitors are susceptible to cross-resistance by mosquito P450s that metabolise pyrethroids

October 7, 2020 - 14:32 -- Open Access
Author(s): 
Lees RS, Ismail HM, Logan RAE, Malone D, Davies R, Anthousi A, Adolfi A, Lycett GJ, Paine MJI
Reference: 
Sci Rep. 2020 Oct 1;10(1):16232

Fenazaquin, pyridaben, tolfenpyrad and fenpyroximate are Complex I inhibitors offering a new mode of action for insecticidal malaria vector control. However, extended exposure to pyrethroid based products such as long-lasting insecticidal nets (LLINs) has created mosquito populations that are largely pyrethroid-resistant, often with elevated levels of P450s that can metabolise and neutralise diverse substrates.

Efficacy of Fludora® Fusion (a mixture of deltamethrin and clothianidin) for indoor residual spraying against pyrethroid-resistant malaria vectors: laboratory and experimental hut evaluation

September 15, 2020 - 14:28 -- Open Access
Author(s): 
Fongnikin A, Houeto N, Agbevo A, Odjo A, Syme T, N'Guessan R, Ngufor C
Reference: 
Parasit Vectors. 2020 Sep 11;13(1):466

A new generation of IRS insecticides which can provide improved and prolonged control of pyrethroid-resistant malaria vector populations are being developed. Fludora® Fusion is a new IRS insecticide containing a mixture of deltamethrin and clothianidin, a neonicotinoid.

Efficacy of Royal Guard, a new alpha-cypermethrin and pyriproxyfen treated mosquito net, against pyrethroid-resistant malaria vectors

July 26, 2020 - 13:47 -- Open Access
Author(s): 
Ngufor C, Agbevo A, Fagbohoun J, Fongnikin A, Rowland M
Reference: 
Sci Rep. 2020 Jul 22;10(1):12227

Royal Guard is a new insecticide-treated bed-net incorporated with a mixture of alpha-cypermethrin and pyriproxyfen (an insect growth regulator). We assessed its efficacy and wash-resistance in laboratory and experimental hut studies following WHO guidelines. Mosquitoes that survived exposure to the net were kept in separate oviposition chambers and observed for the reproductive effects of pyriproxyfen.

Indoor spraying with chlorfenapyr (a pyrrole insecticide) provides residual control of pyrethroid-resistant malaria vectors in southern Benin

July 14, 2020 - 09:47 -- Open Access
Author(s): 
Corine Ngufor, Augustin Fongnikin, Neil Hobbs, Martial Gbegbo, Laurette Kiki, Abibath Odjo, Martin Akogbeto and Mark Rowland
Reference: 
Malaria Journal 2020 19:249, 13 July 2020

New classes of insecticides with novel modes of action, which can provide effective and prolonged control of insecticide-resistant malaria vector populations, are urgently needed for indoor residual spraying. Such insecticides can be included in a rotation plan to manage and prevent further development of resistance in mosquito vectors of malaria. Chlorfenapyr, a novel pyrrole insecticide with a unique mode of action, is being developed as a long-lasting IRS formulation.

ImergardTMWP: A Non-Chemical Alternative for an Indoor Residual Spray, Effective against Pyrethroid-Resistant Anopheles gambiae (s.l.) in Africa

May 27, 2020 - 13:35 -- Open Access
Author(s): 
Deguenon JM, Azondekon R, Roe RM, et al.
Reference: 
Insects. 2020 May 23; 11(5):E322

Malaria is the deadliest mosquito-borne disease and kills predominantly people in sub-Saharan Africa (SSA). The now widespread mosquito resistance to pyrethroids, with rapidly growing resistance to other insecticide classes recommended by the World Health Organization (WHO), may overturn the successes gained in mosquito control in recent years. It is of utmost importance to search for new, inexpensive, and safe alternatives, with new modes of action, that might improve the efficacy of current insecticides.

Effect of Metofluthrin-Impregnated Spatial Repellent Devices Combined with New Long-Lasting Insecticidal Nets (Olyset® Plus) on Pyrethroid-Resistant Malaria Vectors and Malaria Prevalence: Field Trial in South-Eastern Malawi

March 30, 2020 - 10:42 -- Open Access
Author(s): 
Kawada H, Nakazawa S, Shimabukuro K, Ohashi K, Kambewa EA, Foster Pemba D
Reference: 
Jpn J Infect Dis. 2020 Mar 24;73(2):124-131

Long-lasting insecticidal nets (LLINs) experience some operational problems that reduce their effectiveness, such as limited spaces for hanging, biting of mosquitoes outdoors, a shift of key biting time from midnight to dawn or dusk, and development of pyrethroid resistance in mosquitoes. The concept of spatial repellency may be a countermeasure to overcome the above issues.

Evaluation of DawaPlus 3.0 and DawaPlus 4.0, deltamethrin–PBO combination nets against pyrethroid-resistant Anopheles culicifacies in experimental huts in India

January 27, 2020 - 13:40 -- Open Access
Author(s): 
Kasinathan Gunasekaran, Sudhansu Sekhar Sahu, Tharmalingam Vijayakumar, Swaminathan Subramanian, Manju Rahi and Purushothaman Jambulingam
Reference: 
Malaria Journal 2020 19:43, 23 January 2020

The development of resistance in vectors is one of the major impediments for malaria control. Adding synergists to insecticides has proven to be an alternative choice for controlling resistant mosquitoes. DawaPlus 3.0 and DawaPlus 4.0 are new long-lasting insecticidal nets (LLINs) in which deltamethrin and a synergist, piperonyl butoxide (PBO) are added into filaments and their efficacy was tested against resistant malaria vector, Anopheles culicifacies in experimental huts in India.

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