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Quantification of Plasmodium knowlesi versus Plasmodium falciparum in the rhesus liver: implications for malaria vaccine studies in rhesus models

September 1, 2020 - 10:12 -- Open Access
Author(s): 
Melanie J. Shears, Annette M. Seilie, B. Kim Lee Sim, Stephen L. Hoffman and Sean C. Murphy
Reference: 
Malaria Journal 2020 19:313, 31 August 2020

Rhesus macaques are valuable pre-clinical models for malaria vaccine development. The Plasmodium knowlesi/rhesus and Plasmodium falciparum/rhesus models are two established platforms for malaria vaccine testing, and both have previously been used to assess live-attenuated sporozoite vaccines. However, there is evidence that the susceptibility of the rhesus liver to P. knowlesi versus P. falciparum sporozoites likely differs, potentially complicating comparisons between these two platforms.

Identification of Plasmodium falciparum proteoforms from liver stage models

January 14, 2020 - 09:19 -- Open Access
Author(s): 
Benjamin Winer, Kimberly A. Edgel, Vincent R. Gerbasi, et al.
Reference: 
Malaria Journal 2020 19:10, 7 January 2020

Immunization with attenuated malaria sporozoites protects humans from experimental malaria challenge by mosquito bite. Protection in humans is strongly correlated with the production of T cells targeting a heterogeneous population of pre-erythrocyte antigen proteoforms, including liver stage antigens. Currently, few T cell epitopes derived from Plasmodium falciparum, the major aetiologic agent of malaria in humans are known.

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