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protein 2

Plasmodium falciparum Histidine-Rich Protein 2 and 3 Gene Deletions and Their Implications in Malaria Control

May 25, 2020 - 07:54 -- Open Access
Nyataya J, Waitumbi J, Mobegi VA, Noreddin A, El Zowalaty ME
Diseases. 2020 May 20; 8(2):E15

Malaria remains the biggest threat to public health, especially among pregnant women and young children in sub-Saharan Africa. Prompt and accurate diagnosis is critical for effective case management and detection of drug resistance. Conventionally, microscopy and rapid diagnostic tests (RDTs) are the tools of choice for malaria diagnosis. RDTs are simple to use and have been extensively used in the diagnosis of malaria among travelers to malaria-endemic regions, routine case management, and surveillance studies.

NOT Open Access | G-strand binding protein 2 is involved in asexual and sexual development of Plasmodium berghei

January 24, 2020 - 15:02 -- NOT Open Access
Mamoru Niikura, Toshiyuki Fukutomi, Kana Fukui, Shin-Ichi Inoue, Hiroko Asahi, Fumie Kobayashi
Parasitology International, 18 January 2020, 102059

G-strand binding protein 2 (GBP2) is a Ser/Arg-rich (SR) protein involved in mRNA surveillance and nuclear mRNA quality control in yeast. However, the roles of GBP2 in virulence and sexual development in Plasmodium parasites are unclear, although GBP2 is involved in the asexual development of Plasmodium berghei, the rodent malaria parasite. In this study, we investigated the role of GBP2 in virulence and sexual development of P. berghei using gbp2-deleted P. berghei (Δgbp2 parasites).

Genetic polymorphism of histidine rich protein 2 in Plasmodium falciparum isolates from different infection sources in Yunnan Province, China

January 6, 2020 - 16:05 -- Open Access
Ying Dong, Shuping Liu, Yan Deng, Yanchun Xu, Mengni Chen, Yan Liu and Jingpo Xue
Malaria Journal 2019 18:446, 30 December 2019

Failed diagnoses of some falciparum malaria cases by RDTs are constantly reported in recent years. Plasmodium falciparum histidine-rich protein 2 (pfhpr2) gene deficiency has been found to be the major reason of RDTs failure in many countries. This article analysed the deletion of pfhpr2 gene of falciparum malaria cases isolated in Yunnan Province, China.

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