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Indonesia

Molecular analysis reveals a high diversity of Anopheles species in Karama, West Sulawesi, Indonesia

July 30, 2020 - 14:04 -- Open Access
Author(s): 
Davidson JR, Wahid I, Lobo NF, et al.
Reference: 
Parasit Vectors. 2020 Jul 29; 13(1):379

Understanding local Anopheles species compositions and bionomic traits are vital for an effective malaria vector intervention strategy. Though eight malaria vectors, including species complexes, have been documented across the island of Sulawesi, Indonesia, a comprehensive survey linking morphological and molecular species identification has not been conducted in this global hotspot of biodiversity.

Microbial inhibitors active against Plasmodium falciparum dihydroorotate dehydrogenase derived from an Indonesian soil fungus, Talaromyces pinophilus BioMCC-f.T.3979

July 20, 2020 - 15:04 -- Open Access
Author(s): 
Pramisandi A, Dobashi K, Shiomi K, et al.
Reference: 
J Gen Appl Microbiol. 2020 Jul 14

An Indonesian soil fungus, Talaromyces pinophilus BioMCC-f.T.3979 was cultured to find novel scaffolds of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors. We obtained altenusin, which inhibits PfDHODH, with an IC50 value of 5.9 μM, along with other metabolites: mitorubrinol and mitorubrinic acid.

Anopheles sundaicus complex and the presence of Anopheles epiroticus in Indonesia

July 6, 2020 - 16:46 -- Open Access
Author(s): 
Syafruddin D, Lestari YE, Lobo NF, et al.
Reference: 
PLoS Negl Trop Dis. 2020 Jul 2;14(7):e0008385

Anopheles sundaicus s.l. is an important malaria vector primarily found in coastal landscapes of western and central Indonesia. The species complex has a wide geographical distribution in South and Southeast Asia and exhibits ecological and behavioural variability over its range. Studies on understanding the distribution of different members in the complex and their bionomics related to malaria transmission might be important guiding more effective vector intervention strategies.

Potential for a web-based management information system to improve malaria control: An exploratory study in the Lahat District, South Sumatra Province, Indonesia

June 10, 2020 - 15:06 -- Open Access
Author(s): 
Hasyim H, Firdaus F, Prabawa A, Dale P, Harapan H, Groneberg DA, Kuch U, Müller R
Reference: 
PLoS One. 2020 Jun 9;15(6):e0229838

A web-based malaria reporting information system (MRIS) has the potential to improve malaria reporting and management. The aim of this study was to evaluate the existing manual paper-based MRIS and to provide a way to overcome the obstacles by developing a web-based MRIS in Indonesia.

Efficacy of a Spatial Repellent for Control of Malaria in Indonesia: A Cluster-Randomized Controlled Trial

May 21, 2020 - 06:41 -- Open Access
Author(s): 
Syafruddin D, Asih PBS, Achee NL, et al.
Reference: 
Am J Trop Med Hyg. 2020 May 18

A cluster-randomized, double-blinded, placebo-controlled trial was conducted to estimate the protective efficacy (PE) of a spatial repellent (SR) against malaria infection in Sumba, Indonesia. Following radical cure in 1,341 children aged ≥ 6 months to ≤ 5 years in 24 clusters, households were given transfluthrin or placebo passive emanators (devices designed to release vaporized chemical).

Molecular surveillance over 14 years confirms reduction of Plasmodium vivax and falciparum transmission after implementation of Artemisinin-based combination therapy in Papua, Indonesia

May 13, 2020 - 13:51 -- Open Access
Author(s): 
Pava Z, Puspitasari AM, Rumaseb A, Handayuni I, Trianty L, Utami RAS, Tirta YK, Burdam F, Kenangalem E, Wirjanata G, Kho S, Trimarsanto H, Anstey NM, Poespoprodjo JR, Noviyanti R, Price RN, Marfurt J, Auburn S
Reference: 
PLoS Negl Trop Dis 14(5): e0008295

Genetic epidemiology can provide important insights into parasite transmission that can inform public health interventions. The current study compared long-term changes in the genetic diversity and structure of co-endemic Plasmodium falciparum and P. vivax populations. The study was conducted in Papua Indonesia, where high-grade chloroquine resistance in P. falciparum and P. vivax led to a universal policy of Artemisinin-based Combination Therapy (ACT) in 2006.

Variation of preventive practices and its association with malaria infection in eastern Indonesia: Findings from community-based survey

May 12, 2020 - 17:45 -- Open Access
Author(s): 
Ipa M, Widawati M, Laksono AD, Kusrini I, Dhewantara PW
Reference: 
PLoS ONE 15(5): e0232909

Geographical variation may likely influence the effectiveness of prevention efforts for malaria across Indonesia, in addition to factors at the individual level, household level, and contextual factors. This study aimed to describe preventive practices at individual and a household levels applied by rural communities in five provinces in eastern Indonesia and its association with the incidence of malaria among adult (≥15 years) populations.

The risk of morbidity and mortality following recurrent malaria in Papua, Indonesia: a retrospective cohort study

February 25, 2020 - 16:04 -- Open Access
Author(s): 
Dini S, Douglas NM, Poespoprodjo JR, Kenangalem E, Sugiarto P, Plumb ID, Price RN, Simpson JA
Reference: 
BMC Med. 2020 Feb 20;18(1):28

An acute episode of malaria can be followed by multiple recurrent episodes either due to re-infection, recrudescence of a partially treated parasite or, in the case of Plasmodium vivax or P. ovale, relapse from the dormant liver stage of the parasite. The aim of this study was to quantify the impact of recurrent malaria episodes on morbidity and mortality in Papua, Indonesia.

Malaria-related hospitalization during childhood in Papua, Indonesia: A retrospective cohort study

February 11, 2020 - 16:24 -- Open Access
Author(s): 
Nicholas M. Douglas, Enny Kenangalem, Afdhal Hasanuddin, Nicholas M. Anstey, Paulus Sugiarto, Ric N. Price, Jeanne Rini Poespoprodjo
Reference: 
PLoS ONE 15(1):e0228018

In endemic regions, the age distribution of malaria varies according to the infecting Plasmodium species. We aimed to delineate the pattern of malaria-related hospitalization from birth in Timika, Papua–an area co-endemic for P. falciparum and P. vivax

Use of a highly-sensitive rapid diagnostic test to screen for malaria in pregnancy in Indonesia

January 20, 2020 - 15:58 -- Open Access
Author(s): 
Vera T. Unwin, Rukhsana Ahmed, Emily R. Adams, et al.
Reference: 
Malaria Journal 2020 19:28, 16 January 2020

The sensitivity of rapid diagnostic tests (RDTs) for malaria is inadequate for detecting low-density, often asymptomatic infections, such as those that can occur when screening pregnant women for malaria. The performance of the Alere™ Ultra-sensitive Malaria Ag Plasmodium falciparum RDT (uRDT) was assessed retrospectively in pregnant women in Indonesia.

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