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NOT Open Access | Alkaloids from the root of Indonesian Annona muricata L

February 3, 2021 - 14:39 -- NOT Open Access
Nugraha AS, Haritakun R, Lambert JM, Dillon CT, Keller PA
Nat Prod Res. 2021 Feb;35(3):481-489

Annona muricata L. has been used traditionally in Indonesia to treat disease. Phytochemical studies on the alkaloid fractions from the root of Annona muricata L. from Malang-Indonesia resulted in the isolation of an unreported benzylisoquinoline alkaloid (+)-xylopine 5 as well as four known alkaloids (1-4).

Cost-effectiveness of intermittent preventive treatment with dihydroartemisinin-piperaquine versus single screening and treatment for the control of malaria in pregnancy in Papua, Indonesia: a provider perspective analysis from a cluster-randomised trial

December 3, 2020 - 12:26 -- Open Access
Paintain L, Hill J, Webster J, et al.
Lancet Glob Health. 2020 Dec;8(12):e1524-e1533

Malaria infection during pregnancy is associated with serious adverse maternal and birth outcomes. A randomised controlled trial in Papua, Indonesia, comparing the efficacy of intermittent preventive treatment with dihydroartemisinin-piperaquine with the current strategy of single screening and treatment showed that intermittent preventive treatment is a promising alternative treatment for the reduction of malaria in pregnancy. We aimed to estimate the incremental cost-effectiveness of intermittent preventive treatment with dihydroartemisinin-piperaquine compared with single screening and treatment with dihydroartemisinin-piperaquine.

Significant Symptoms and Non-Symptom-Related Factors for Malaria Diagnosis in Endemic Regions of Indonesia

December 3, 2020 - 12:15 -- Open Access
Bria YP, Yeh CH, Bedingfield S
Int J Infect Dis. 2020 Nov 26:S1201-9712(20)32490-5

This study aims to identify significant symptoms and non-symptom-related factors for malaria diagnosis in endemic regions of Indonesia.

Defining malaria risks among forest workers in Aceh, Indonesia: a formative assessment

December 2, 2020 - 07:54 -- Open Access
Lenny L. Ekawati, Kelly C. Johnson, Adam Bennett, et al.
Malaria Journal 2020 19:441, 30 November 2020

Following a dramatic decline of malaria cases in Aceh province, geographically-based reactive case detection (RACD) was recently evaluated as a tool to improve surveillance with the goal of malaria elimination. While RACD detected few cases in households surrounding index cases, engaging in forest work was identified as a risk factor for malaria and infections from Plasmodium knowlesi—a non-human primate malaria parasite—were more common than expected. This qualitative formative assessment was conducted to improve understanding of malaria risk from forest work and identify strategies for targeted surveillance among forest workers, including adapting reactive case detection.

The risk of adverse clinical outcomes following treatment of Plasmodium vivax malaria with and without primaquine in Papua, Indonesia

November 12, 2020 - 15:44 -- Open Access
Thriemer K, Poespoprodjo JR, Kenangalem E, Douglas NM, Sugiarto P, Anstey NM, Simpson JA, Price RN
PLoS Negl Trop Dis. 2020 Nov 11;14(11):e0008838

The widespread use of primaquine (PQ) radical cure for P. vivax, is constrained by concerns over its safety. We used routinely collected patient data to compare the overall morbidity and mortality in patients treated with and without PQ without prior testing of Glucose-6-Phosphate-Dehydrogenase (G6PD) deficiency in Papua, Indonesia, where there is a low prevalence of G6PD deficiency. Records were collated from patients older than 1 year, with P. vivax infection, who were treated with an artemisinin combination therapy (ACT).

NOT Open Access | Spatial analysis of malaria in Kotabaru, South Kalimantan, Indonesia: an evaluation to guide elimination strategies

November 11, 2020 - 13:09 -- NOT Open Access
Juhairiyah J, Andiarsa D, Indriyati L, Ridha MR, Prasodjo RS, Dhewantara PW
Trans R Soc Trop Med Hyg. 2020 Nov 9:traa125

Malaria remains a significant public health concern in Indonesia. Knowledge about spatial patterns of the residual malaria hotspots is critical to help design elimination strategies in Kotabaru district, South Kalimantan, Indonesia.

Molecular analysis reveals a high diversity of Anopheles species in Karama, West Sulawesi, Indonesia

July 30, 2020 - 14:04 -- Open Access
Davidson JR, Wahid I, Lobo NF, et al.
Parasit Vectors. 2020 Jul 29; 13(1):379

Understanding local Anopheles species compositions and bionomic traits are vital for an effective malaria vector intervention strategy. Though eight malaria vectors, including species complexes, have been documented across the island of Sulawesi, Indonesia, a comprehensive survey linking morphological and molecular species identification has not been conducted in this global hotspot of biodiversity.

Microbial inhibitors active against Plasmodium falciparum dihydroorotate dehydrogenase derived from an Indonesian soil fungus, Talaromyces pinophilus BioMCC-f.T.3979

July 20, 2020 - 15:04 -- Open Access
Pramisandi A, Dobashi K, Shiomi K, et al.
J Gen Appl Microbiol. 2020 Jul 14

An Indonesian soil fungus, Talaromyces pinophilus BioMCC-f.T.3979 was cultured to find novel scaffolds of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors. We obtained altenusin, which inhibits PfDHODH, with an IC50 value of 5.9 μM, along with other metabolites: mitorubrinol and mitorubrinic acid.

Anopheles sundaicus complex and the presence of Anopheles epiroticus in Indonesia

July 6, 2020 - 16:46 -- Open Access
Syafruddin D, Lestari YE, Lobo NF, et al.
PLoS Negl Trop Dis. 2020 Jul 2;14(7):e0008385

Anopheles sundaicus s.l. is an important malaria vector primarily found in coastal landscapes of western and central Indonesia. The species complex has a wide geographical distribution in South and Southeast Asia and exhibits ecological and behavioural variability over its range. Studies on understanding the distribution of different members in the complex and their bionomics related to malaria transmission might be important guiding more effective vector intervention strategies.

Potential for a web-based management information system to improve malaria control: An exploratory study in the Lahat District, South Sumatra Province, Indonesia

June 10, 2020 - 15:06 -- Open Access
Hasyim H, Firdaus F, Prabawa A, Dale P, Harapan H, Groneberg DA, Kuch U, Müller R
PLoS One. 2020 Jun 9;15(6):e0229838

A web-based malaria reporting information system (MRIS) has the potential to improve malaria reporting and management. The aim of this study was to evaluate the existing manual paper-based MRIS and to provide a way to overcome the obstacles by developing a web-based MRIS in Indonesia.


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