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Epidemiology of Malaria in East Nusa Tenggara Province in Indonesia: Protocol for a Cross-sectional Study

April 14, 2021 - 08:12 -- Open Access
Guntur RD, Kingsley J, Islam FMA
JMIR Res Protoc. 2021 Apr 9;10(4):e23545

Malaria is a global pandemic that results in approximately 228 million cases globally; 3.5% of these cases are in Southeast Asian countries, including Indonesia. Following the World Health Organization (WHO) initiative, Indonesia is in the process of achieving malaria-free zone status by 2030. However, the eastern part of Indonesia, including the East Nusa Tenggara Province (ENTP), still has a disproportionately high rate of malaria.

Allelic diversity of merozoite surface protein genes (msp1 and msp2) and clinical manifestations of Plasmodium falciparum malaria cases in Aceh, Indonesia

April 14, 2021 - 08:00 -- Open Access
Kurnia Fitri Jamil, Nandha Rizki Pratama, Din Syafruddin, et al.
Malaria Journal 2021 20:182, 13 April 2021

The malaria control programme in Indonesia has successfully brought down malaria incidence in many parts in Indonesia, including Aceh Province. Clinical manifestation of reported malaria cases in Aceh varied widely from asymptomatic, mild uncomplicated to severe and fatal complications. The present study aims to explore the allelic diversity of merozoite surface protein 1 gene (msp1) and msp2 among the Plasmodium falciparum isolates in Aceh Province and to determine their potential correlation with the severity of malaria clinical manifestation.

Gametocyte carriage of Plasmodium falciparum (pfs25) and Plasmodium vivax (pvs25) during mass screening and treatment in West Timor, Indonesia: a longitudinal prospective study

April 14, 2021 - 07:50 -- Open Access
Ayleen Kosasih, Cristian Koepfli, M. Sopiyudin Dahlan, William A. Hawley, J. Kevin Baird, Ivo Mueller, Neil F. Lobo and Inge Sutanto
Malaria Journal 2021 20:177, 9 April 2021

A goal of malaria epidemiological interventions is the detection and treatment of parasite reservoirs in endemic areas—an activity that is expected to reduce local transmission. Since the gametocyte is the only transmissible stage from human host to mosquito vector, this study evaluated the pre and post presence of gametocytes during a mass screening and treatment (MST) intervention conducted during 2013 in East Nusa Tenggara, Indonesia.

A participatory approach to address within‐country cross‐border malaria: the case of Menoreh Hills in Java, Indonesia

March 10, 2021 - 15:13 -- Open Access
Riris Andono Ahmad, Astri Ferdiana, Henry Surendra, Tyrone Reden Sy, Deni Herbianto, Theodola Baning Rahayujati, Dwi Sarwani Sri Rejeki and E. Elsa Herdiana Murhandarwati
Malaria Journal 2021 20:137, 6 March 2021

Malaria remains a significant public health issue in Indonesia. Most of the endemic areas are in the eastern parts of Indonesia, but there are a few remaining foci of persistent endemic malaria in Java, particularly in Menoreh Hills, a region bordering three districts of two provinces on this island. Despite a commitment to build a partnership to eliminate cross-border malaria, there is a lack of understanding of how this partnership might be translated into an implementable strategic plan. The study aims to provide evidence of how a participatory approach was used to strengthen the cross-border collaboration and stakeholders’ capacity to develop a joint strategic, operational, and costing plan for cross-border malaria elimination.

Haematological profile of children with malaria in Sorong, West Papua, Indonesia

March 10, 2021 - 13:58 -- Open Access
Syilvia Jiero and Ayodhia Pitaloka Pasaribu
Malaria Journal 2021 20:126, 4 March 2021

Malaria remains a major public health problem in Indonesian Papua, with children under five years of age being the most affected group. Haematological changes, such as cytopenia that occur during malaria infection have been suggested as potential predictors and can aid in the diagnosis of malaria. This study aimed to assess the haematological alterations associated with malaria infection in children presenting with signs and symptoms of malaria.

NOT Open Access | Alkaloids from the root of Indonesian Annona muricata L

February 3, 2021 - 14:39 -- NOT Open Access
Nugraha AS, Haritakun R, Lambert JM, Dillon CT, Keller PA
Nat Prod Res. 2021 Feb;35(3):481-489

Annona muricata L. has been used traditionally in Indonesia to treat disease. Phytochemical studies on the alkaloid fractions from the root of Annona muricata L. from Malang-Indonesia resulted in the isolation of an unreported benzylisoquinoline alkaloid (+)-xylopine 5 as well as four known alkaloids (1-4).

Cost-effectiveness of intermittent preventive treatment with dihydroartemisinin-piperaquine versus single screening and treatment for the control of malaria in pregnancy in Papua, Indonesia: a provider perspective analysis from a cluster-randomised trial

December 3, 2020 - 12:26 -- Open Access
Paintain L, Hill J, Webster J, et al.
Lancet Glob Health. 2020 Dec;8(12):e1524-e1533

Malaria infection during pregnancy is associated with serious adverse maternal and birth outcomes. A randomised controlled trial in Papua, Indonesia, comparing the efficacy of intermittent preventive treatment with dihydroartemisinin-piperaquine with the current strategy of single screening and treatment showed that intermittent preventive treatment is a promising alternative treatment for the reduction of malaria in pregnancy. We aimed to estimate the incremental cost-effectiveness of intermittent preventive treatment with dihydroartemisinin-piperaquine compared with single screening and treatment with dihydroartemisinin-piperaquine.

Significant Symptoms and Non-Symptom-Related Factors for Malaria Diagnosis in Endemic Regions of Indonesia

December 3, 2020 - 12:15 -- Open Access
Bria YP, Yeh CH, Bedingfield S
Int J Infect Dis. 2020 Nov 26:S1201-9712(20)32490-5

This study aims to identify significant symptoms and non-symptom-related factors for malaria diagnosis in endemic regions of Indonesia.

Defining malaria risks among forest workers in Aceh, Indonesia: a formative assessment

December 2, 2020 - 07:54 -- Open Access
Lenny L. Ekawati, Kelly C. Johnson, Adam Bennett, et al.
Malaria Journal 2020 19:441, 30 November 2020

Following a dramatic decline of malaria cases in Aceh province, geographically-based reactive case detection (RACD) was recently evaluated as a tool to improve surveillance with the goal of malaria elimination. While RACD detected few cases in households surrounding index cases, engaging in forest work was identified as a risk factor for malaria and infections from Plasmodium knowlesi—a non-human primate malaria parasite—were more common than expected. This qualitative formative assessment was conducted to improve understanding of malaria risk from forest work and identify strategies for targeted surveillance among forest workers, including adapting reactive case detection.

The risk of adverse clinical outcomes following treatment of Plasmodium vivax malaria with and without primaquine in Papua, Indonesia

November 12, 2020 - 15:44 -- Open Access
Thriemer K, Poespoprodjo JR, Kenangalem E, Douglas NM, Sugiarto P, Anstey NM, Simpson JA, Price RN
PLoS Negl Trop Dis. 2020 Nov 11;14(11):e0008838

The widespread use of primaquine (PQ) radical cure for P. vivax, is constrained by concerns over its safety. We used routinely collected patient data to compare the overall morbidity and mortality in patients treated with and without PQ without prior testing of Glucose-6-Phosphate-Dehydrogenase (G6PD) deficiency in Papua, Indonesia, where there is a low prevalence of G6PD deficiency. Records were collated from patients older than 1 year, with P. vivax infection, who were treated with an artemisinin combination therapy (ACT).


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