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Lagos

Socio-economic behavioural indicators of falciparum malaria parasitaemia and moderate to severe anaemia among pregnant women attending antenatal clinics in Lagos, Southwest Nigeria

November 10, 2020 - 13:54 -- Open Access
Author(s): 
Adeola Y. Olukosi, Abiodun Olakiigbe, Bamigboye M. Afolabi, et al.
Reference: 
Malaria Journal 2020 19:393, 7 November 2020

Incidence of malaria and anaemia are of public health importance especially in pregnant women in endemic regions, due to the negative health consequences to the mother and fetus. This study aimed to assess the pattern of falciparum malaria infection and anaemia, based on malaria prevention methods practiced by participants.

High multiple mutations of Plasmodium falciparum-resistant genotypes to sulphadoxine-pyrimethamine in Lagos, Nigeria

July 14, 2020 - 15:34 -- Open Access
Author(s): 
Quan H, Igbasi U, Oyibo W, Omilabu S, Chen SB, Shen HM, Okolie C, Chen JH, Zhou XN
Reference: 
Infect Dis Poverty. 2020 Jul 11; 9(1):91

Plasmodium falciparum-resistance to sulphadoxine-pyrimethamine (SP) has been largely reported among pregnant women. However, the profile of resistance markers to SP dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) in the general population are varied and not frequently monitored. Currently, SP is used as partner drug for artemisinin combination therapy (SP-artesunate) in some sub-Saharan African countries or as a prophylactic drug in intermittent preventive treatment of malaria during pregnancy and infants and in seasonal malaria chemoprevention (SMC). Profiling of P. falciparum-resistant genotypes to SP is dynamic and critical in providing data that would be useful for malaria control programmes. This study assessed the profile of dhfr and dhps genes genotypes among individuals with malaria in Lagos, Nigeria.

A 2-month intervention study of preventive clothing against mosquito bites among malnourished and well-nourished children under 5 years of age living on the Atlantic Ocean Coast of Lagos, Southwest Nigeria

February 10, 2020 - 16:18 -- Open Access
Author(s): 
Bamgboye M. Afolabi, Titilola M. Afolabi, Abiodun Ogunwale and Adewunmi Aiyesetenikan
Reference: 
Malaria Journal 2020 19:61, 5 February 2020

Malnutrition is appreciated as a global leading paediatric burden that indirectly or directly contributes to child mortality. In children, malnutrition has profound effects on health and development; and has been associated with poor outcomes in paediatric diseases. However, it is not clear if malnourished children are at an increased risk of having malaria. This study was conducted to evaluate the risk of malaria infection in children with malnutrition.

Asymptomatic falciparum Malaria and its Effects on Type 2 Diabetes Mellitus Patients in Lagos, Nigeria

January 20, 2020 - 15:07 -- Open Access
Author(s): 
Udoh BE, Iwalokun BA, Etukumana E, Amoo J
Reference: 
Saudi J Med Med Sci. 2020 Jan-Apr; 8(1):32-40

Asymptomatic malaria (ASM) constitutes a reservoir of malaria parasites that sustain transmission and threaten elimination efforts. Studies have also shown a significant relation between insulin resistance and malaria infection. However, data on the clinical effects of ASM and its patterns of carriage among adult malaria patients is limited.

Genetic polymorphisms in malaria vaccine candidate Plasmodium falciparum reticulocyte-binding protein homologue-5 among populations in Lagos, Nigeria

January 7, 2020 - 15:09 -- Open Access
Author(s): 
Olusola Ajibaye, Akinniyi A. Osuntoki, Alfred Amambua-Ngwa, et al.
Reference: 
Malaria Journal 2020 19:6, 6 January 2020

Vaccines are the most reliable alternative to elicit sterile immunity against malaria but their development has been hindered by polymorphisms and strain-specificity in previously studied antigens. New vaccine candidates are therefore urgently needed. Highly conserved Plasmodium falciparum reticulocyte-binding protein homologue-5 (PfRH5) has been identified as a potential candidate for anti-disease vaccine development. PfRH5 is essential for erythrocyte invasion by merozoites and crucial for parasite survival. However, there is paucity of data on the extent of genetic variations on PfRH5 in field isolates of Plasmodium falciparum. This study described genetic polymorphisms at the high affinity binding polypeptides (HABPs) 36718, 36727, 36728 of PfRH5 in Nigerian isolates of P. falciparum. This study tested the hypothesis that only specific conserved B and T cell epitopes on PfRH5 HABPs are crucial for vaccine development.

High cases of submicroscopic Plasmodium falciparum infections in a suburban population of Lagos, Nigeria

December 30, 2019 - 14:21 -- Open Access
Author(s): 
Florence A. Umunnakwe, Emmanuel T. Idowu, Olusola Ajibaye, Blessed Etoketim, Samuel Akindele, Aminat O. Shokunbi, Olubunmi A. Otubanjo, Gordon A. Awandare, Alfred Amambua-Ngwa and Kolapo M. Oyebola
Reference: 
Malaria Journal 2019 18:433,19 December 2019

Asymptomatic malaria parasites are significant sources of infections for onward malaria transmission. Conventional tools for malaria diagnosis such as microscopy and rapid diagnostic test kits (RDT) have relatively low sensitivity, hence the need for alternative tools for active screening of such low-density infections.

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