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west africa

NOT Open Access | Factors Affecting Willingness to Use Indoor Residual Spraying Among Pregnant Women Attending Antenatal Care in Hyperendemic State of West Africa: A Random Survey

August 4, 2021 - 12:02 -- NOT Open Access
Oladoyinbo TO, Adeogun AO, Babalola AS, Babatunde M, Ladipo OT, Olarinde TI, Oyedemi ID
J Med Entomol. 2021 Jul 30:tjab132

This study assessed the perception of pregnant women on indoor residual spraying (IRS), documented acceptability, and factors that significantly dictate willingness to use IRS among the pregnant women attending antenatal clinic in Ibadan Nigeria. A structured questionnaire was used to obtain relevant information from 500 pregnant women. Descriptive and principal component analysis (PCA) were done at 5% level of significance. Majority of the pregnant women had between good and fair knowledge of IRS. Less than 70% of the respondents were willing to allow IRS in their homes.

Characterization of resistance profile (intensity and mechanisms) of Anopheles gambiae in three communes of northern Benin, West Africa

July 28, 2021 - 15:13 -- Open Access
Casimir Dossou Kpanou, Hermann W. Sagbohan, Martin Akogbéto, et al.
Malaria Journal 2021 20:328, 27 July 2021

The selection and the spread of insecticide resistance in malaria vectors to the main classes of insecticides used in vector control tools are a major and ongoing challenge to malaria vector control programmes. This study aimed to determine the intensity of vector resistance to insecticides in three regions of Benin with different agro-ecological characteristics.

Not Open Access | The impact of indoor residual spraying on Plasmodium falciparum microsatellite variation in an area of high seasonal malaria transmission in Ghana, West Africa

June 22, 2021 - 14:44 -- NOT Open Access
Argyropoulos DC, Ruybal-Pesántez S, Deed SL, Oduro AR, Dadzie SK, Appawu MA, Asoala V, Pascual M, Koram KA, Day KP, Tiedje KE
Mol Ecol. 2021 Jun 18

Here we report the first population genetic study to examine the impact of indoor residual spraying (IRS) on Plasmodium falciparum in humans. This study was conducted in an area of high seasonal malaria transmission in Bongo District, Ghana. IRS was implemented during the dry season (November - May) in three consecutive years between 2013 and 2015 to reduce transmission and attempt to bottleneck the parasite population in humans towards lower diversity with greater linkage disequilibrium. The study was done against a background of widespread use of long-lasting insecticidal nets, typical for contemporary malaria control in West Africa.

NOT Open Access | Metabolome modulation of the host adaptive immunity in human malaria

June 15, 2021 - 15:13 -- NOT Open Access
Abdrabou W, Dieng MM, Diawara A, Sermé SS, Almojil D, Sombié S, Henry NB, Kargougou D, Manikandan V, Soulama I, Idaghdour Y
Nat Metab. 2021 Jun 10

Host responses to infection with the malaria parasite Plasmodium falciparum vary among individuals for reasons that are poorly understood. Here we reveal metabolic perturbations as a consequence of malaria infection in children and identify an immunosuppressive role of endogenous steroid production in the context of P. falciparum infection. We perform metabolomics on matched samples from children from two ethnic groups in West Africa, before and after infection with seasonal malaria.

A Difficult Diagnosis of Plasmodium ovale Malaria

May 13, 2021 - 12:34 -- Open Access
Santos-Reis A, Nina J
Acta Med Port. 2021 May 12

Malaria is a major cause of suffering, disease, and death worldwide and is considered the most important of all human parasitic diseases. Malaria is still endemic in most tropical and sub-tropical areas and globalization has contributed to an increase of imported cases around the world. We report a Plasmodium ovale infection in a traveler with recent return from a long land trip across West Africa.

Multiple Resistance Mechanisms to Pyrethroids Insecticides in Anopheles gambiae sensu lato Population From Mali, West Africa

April 29, 2021 - 07:16 -- Open Access
Keïta M, Sogoba N, Kané F, Traoré B, Zeukeng F, Coulibaly B, Sodio AB, Traoré SF, Djouaka R, Doumbia S
J Infect Dis. 2021 Apr 27;223(Supplement_2):S81-S90

Insecticide-based vector control is responsible for reducing malaria mortality and morbidity. Its success depends on a better knowledge of the vector, its distribution, and resistance status to the insecticides used. In this paper, we assessed Anopheles gambiae sensu lato (A gambiae s.l.) population resistance to pyrethroids in different ecological settings.

Testing configurations of attractive toxic sugar bait (ATSB) stations in Mali, West Africa, for improving the control of malaria parasite transmission by vector mosquitoes and minimizing their effect on non-target insects

April 20, 2021 - 16:00 -- Open Access
Rabiatou A. Diarra, Mohamed M. Traore, Günter C. Müller, et al.
Malaria Journal 2021 20:184, 14 April 2021

Application methods of |Attractive Toxic Sugar Baits (ATSB) need to be improved for wide-scale use, and effects on non-target organisms (NTOs) must be assessed. The goals of this study were to determine, at the village level, the effect of different configurations of bait stations to (1) achieve < 25% Anopheles mosquito vector daily feeding rate for both males and females and (2) minimize the effect on non-target organisms.

Systematic identification of plausible pathways to potential harm via problem formulation for investigational releases of a population suppression gene drive to control the human malaria vector Anopheles gambiae in West Africa

March 30, 2021 - 14:07 -- Open Access
John B. Connolly, John D. Mumford, Silke Fuchs, Geoff Turner, Camilla Beech, Ace R. North and Austin Burt
Malaria Journal 2021 20:170, 29 March 2021

Population suppression gene drive has been proposed as a strategy for malaria vector control. A CRISPR-Cas9-based transgene homing at the doublesex locus (dsxFCRISPRh) has recently been shown to increase rapidly in frequency in, and suppress, caged laboratory populations of the malaria mosquito vector Anopheles gambiae. Here, problem formulation, an initial step in environmental risk assessment (ERA), was performed for simulated field releases of the dsxFCRISPRh transgene in West Africa.

Seeking research questions from implementers: considerations for leveraging ground actors research needs in the fight against malaria in West Africa

March 10, 2021 - 15:18 -- Open Access
Tete S. Amouh, Saidou Malam Ekoye, Césaire D. Ahanhanzo, Tinga Robert Guiguemdé and Issiaka Sombié
Malaria Journal 2021 20:140, 8 March 2021

To strengthen the fight against malaria, it is imperative to identify weaknesses and possible solutions in order to improve programmes implementation. This study reports experiences gained from collaboration between decision-makers and researchers from a World Bank project (Malaria and Neglected Tropical Diseases in the Sahel, SM/NTD). The objectives of this paper were to identify bottlenecks in malaria programme implementation as well as related research questions they bring up.

Improved BioGents® Sentinel trap with heat (BGSH) for outdoor collections of Anopheline species in Burkina Faso and Mali, West Africa

February 2, 2021 - 16:32 -- Open Access
Guindo A, Epopa PS, Doumbia S, Millogo AA, Diallo B, Yao FA, Yagoure B, Tripet F, Diabate A, Coulibaly MB
Parasit Vectors. 2021 Jan 28;14(1):82

Since the late 1990s, malaria control programmes have relied extensively on mass bednet distribution and indoor residual spraying. Both interventions use pesticides and target mosquitoes coming indoors either to feed or to rest. Unfortunately, these intensified vector control campaigns have resulted in mosquito populations with high levels of resistance to most of the chemical compounds used against them and which are increasingly exophagic and exophillic, hence difficult to monitor indoors. Consequently, there is an urgent need for novel tools to sample outdoor anopheline populations for monitoring interventions and disease surveillance programmes.


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