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The development and evaluation of a self-marking unit to estimate malaria vector survival and dispersal distance

December 30, 2019 - 15:00 -- Open Access
Adam Saddler, Katharina S. Kreppel, Nakul Chitnis, Thomas A. Smith, Adrian Denz, Jason D. Moore, Mgeni M. Tambwe and Sarah J. Moore
Malaria Journal 2019 18:441, 23 December 2019

A clear understanding of mosquito biology is fundamental to the control efforts of mosquito-borne diseases such as malaria. Mosquito mark-release-recapture (MMRR) experiments are a popular method of measuring the survival and dispersal of disease vectors; however, examples with African malaria vectors are limited. Ethical and technical difficulties involved in carrying out MMRR studies may have held back research in this area and, therefore, a device that marks mosquitoes as they emerge from breeding sites was developed and evaluated to overcome the problems of MMRR.

IL35 modulation altered survival, cytokine environment and histopathological consequences during malaria infection in mice

December 30, 2019 - 14:23 -- Open Access
Ramatu Omenesa Bello, Maizaton Atmadini Abdullah, Rusliza Basir, et al.
Malaria Journal 2019 18:434, 19 December 2019

The immune modulating potential of IL-35 in multiple human disorders has been reported. Consequent upon the recognition of inflammatory cytokine activation and its preponderance for mediating pathology during malaria infection, the study aimed to characterize the expression and functional contribution(s) of IL-35 in Plasmodium berghei (strain ANKA) infected mice.

Terminalia albida treatment improves survival in experimental cerebral malaria through reactive oxygen species scavenging and anti-inflammatory properties

December 30, 2019 - 14:15 -- Open Access
Aissata Camara, Mohamed Haddad, Agnès Aubouy, et al.
Malaria Journal 2019 18:431,18 December 2019

The development of Plasmodium resistance to the last effective anti-malarial drugs necessitates the urgent development of new anti-malarial therapeutic strategies. To this end, plants are an important source of new molecules. The objective of this study was to evaluate the anti-malarial effects of Terminalia albida, a plant used in Guinean traditional medicine, as well as its anti-inflammatory and antioxidant properties, which may be useful in treating cases of severe malaria.

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