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Greater Mekong Subregion

Targeting high risk forest goers for malaria elimination: a novel approach for investigating forest malaria to inform program intervention in Vietnam

October 20, 2020 - 16:18 -- Open Access
Author(s): 
Canavati SE, Kelly GC, Quintero CE, Vo TH, Tran LK, Ngo TD, Tran DT, Edgel KA, Martin NJ
Reference: 
BMC Infect Dis. 2020 Oct 15;20(1):757

Individuals that work and sleep in remote forest and farm locations in the Greater Mekong Subregion continue to remain at high risk of both acquiring and transmitting malaria. These difficult-to-access population groups largely fall outside the reach of traditional village-centered interventions, presenting operational challenges for malaria programs. In Vietnam, over 60% of malaria cases are thought to be individuals who sleep in forests or on farms. New malaria elimination strategies are needed in countries where mobile and migrant workers frequently sleep outside of their homes. The aim of this study was to apply targeted surveillance-response based investigative approaches to gather location-specific data on confirmed malaria cases, with an objective to identify associated malaria prevention, treatment and risk behaviors of individuals sleeping in remote forest and farms sites in Vietnam.

Importance of kelch 13 C580Y mutation in the studies of artemisinin resistance in Plasmodium falciparum in Greater Mekong Subregion

October 7, 2020 - 16:23 -- Open Access
Author(s): 
Zaw MT, Lin Z, Emran NA
Reference: 
J Microbiol Immunol Infect. 2020 Oct;53(5):676-681

The mortality caused by Plasmodium falciparum was reduced by Artemisinin (ART) and ART combination therapy (ACT). However, Artemisinin resistance (ART-R) emerge during 2008 in Cambodia and spread to Greater Mekong Subregion (GMS).

NOT Open Access | Lineage-Specific Expansion of Plasmodium falciparum Parasites With pfhrp2 Deletion in the Greater Mekong Subregion

October 7, 2020 - 14:48 -- NOT Open Access
Author(s): 
Gibbons J, Qin J, Malla P, Wang Z, Brashear A, Wang C, Miao J, Adams JH, Kim K, Jiang R, Cui L
Reference: 
J Infect Dis. 2020 Oct 1;222(9):1561-1569

Deletion of the pfhrp2 gene in Plasmodium falciparum can lead to false-negative rapid diagnostic test (RDT) results, constituting a major challenge for evidence-based malaria treatment. Here we analyzed the whole genome sequences of 138 P. falciparum clinical samples collected from the China-Myanmar boarder for pfhrp2 and pfhrp3 gene deletions.

Current vector research challenges in the greater Mekong subregion for dengue, Malaria, and Other Vector-Borne Diseases: A report from a multisectoral workshop March 2019

August 3, 2020 - 15:40 -- Open Access
Author(s): 
Christofferson RC, Parker DM, Overgaard HJ, Hii J, Devine G, Wilcox BA, Nam VS, Abubakar S, Boyer S, Boonnak K, Whitehead SS, Huy R, Rithea L, Sochantha T, Wellems TE, Valenzuela JG, Manning JE
Reference: 
PLoS Negl Trop Dis 14(7): e0008302

Vector-borne diseases (VBDs) are a significant and growing threat to the health of the 326 million people living in the Greater Mekong Subregion (GMS) (Fig 1). The GMS is a diverse landscape of cities, rural agricultural communities, forests, deltas, wooded hills, and mountains in the six countries along the Mekong River basin.

Molecular epidemiology of resistance to antimalarial drugs in the Greater Mekong subregion: an observational study

July 20, 2020 - 15:55 -- Open Access
Author(s): 
Imwong M, Dhorda M, White NJ, et al.
Reference: 
Lancet Infect Dis. 2020 Jul 14:S1473-3099(20)30228-0

The Greater Mekong subregion is a recurrent source of antimalarial drug resistance in Plasmodium falciparum malaria. This study aimed to characterise the extent and spread of resistance across this entire region between 2007 and 2018.

NOT Open Access | Lineage-specific expansion of Plasmodium falciparum parasites with pfhrp2 deletion in the Greater Mekong Subregion

May 13, 2020 - 13:55 -- NOT Open Access
Author(s): 
Gibbons J, Qin J, Malla P, Wang Z, Brashear A, Wang C, Miao J, Adams JH, Kim K, Jiang R, Cui L
Reference: 
J Infect Dis. 2020 May 9. pii: jiaa250

Deletion of the pfhrp2 gene in Plasmodium falciparum can lead to false negative RDT results, constituting a major challenge for evidence-based malaria treatment. Here we analyzed the whole genome sequences of 138 P. falciparum clinical samples collected from the China-Myanmar boarder for pfhrp2 and pfhrp3 gene deletions. We found pfhrp2 and pfhrp3 deletions in 9.4% and 3.6% samples, respectively, with no samples harboring deletions of both genes.

Plasmodium vivax HAP2/GCS1 gene exhibits limited genetic diversity among parasite isolates from the Greater Mekong Subregion

April 13, 2020 - 13:55 -- Open Access
Author(s): 
Li D, Yu C, Cao Y, et al.
Reference: 
Parasit Vectors. 2020 Apr 7;13(1):175

Antigens expressed in sexual stages of the malaria parasites are targets of transmission-blocking vaccines (TBVs). HAP2/GCS1, a TBV candidate, is critical for fertilization in Plasmodium. Here, the genetic diversity of PvHAP2 was studied in Plasmodium vivax parasite populations from the Greater Mekong Subregion (GMS).

Intracluster correlation coefficients in the Greater Mekong Subregion for sample size calculations of cluster randomized malaria trials

December 30, 2019 - 14:04 -- Open Access
Author(s): 
Pimnara Peerawaranun, Jordi Landier, Mavuto Mukaka, et al.
Reference: 
Malaria Journal 2019 18:428, 18 December 2019

Sample size calculations for cluster randomized trials are a recognized methodological challenge for malaria research in pre-elimination settings. Positively correlated responses from the participants in the same cluster are a key feature in the estimated sample size required for a cluster randomized trial. The degree of correlation is measured by the intracluster correlation coefficient (ICC) where a higher coefficient suggests a closer correlation hence less heterogeneity within clusters but more heterogeneity between clusters.

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