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survival assay

Anti-malarial ozonides OZ439 and OZ609 tested at clinically relevant compound exposure parameters in a novel ring-stage survival assay

December 23, 2019 - 15:09 -- Open Access
Tags: 
anti-malarial, ozonides, OZ439, OZ609, parameters, ring-stage, survival assay
Author(s): 
Annabelle Walz, Didier Leroy, Nicole Andenmatten, Pascal Mäser and Sergio Wittlin
Reference: 
Malaria Journal 2019 18:427, 18 December 2019

Drug efficacy against kelch 13 mutant malaria parasites can be determined in vitro with the ring-stage survival assay (RSA). The conventional assay protocol reflects the exposure profile of dihydroartemisinin.

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