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Controlled human malaria infection with a clone of Plasmodium vivax with high quality genome assembly

October 16, 2021 - 12:54 -- Open Access
Minassian AM, Themistocleous Y, Draper SJ, et al.
JCI Insight. 2021 Oct 5:e152465

Controlled human malaria infection (CHMI) provides a highly informative means to investigate host-pathogen interactions and enable in vivo proof-of-concept efficacy testing of new drugs and vaccines. However, unlike Plasmodium falciparum, well-characterized P. vivax parasites that are safe and suitable for use in modern CHMI models are limited. Here, two healthy malaria-naïve UK adults with universal donor blood group were safely infected with a clone of P. vivax from Thailand by mosquito-bite CHMI. Parasitemia developed in both volunteers and, prior to treatment, each volunteer donated blood to produce a cryopreserved stabilate of infected red blood cells.

NOT Open Access | Letter Regarding Kamau et al: 2021 Safety and Tolerability of Mosquito-Bite Induced Controlled Human Infection with P. vivax in Malaria-Naive Study Participants - Clinical Profile and Utility of Molecular Diagnostic Methods

October 16, 2021 - 11:56 -- NOT Open Access
Odedra A, Woodford J, Chalon S, Barber BE, McCarthy JS
J Infect Dis. 2021 Oct 5:jiab502

No abstract available

An update on the mosquito fauna and mosquito-borne diseases distribution in Cameroon

October 13, 2021 - 12:32 -- Open Access
Bamou R, Mayi MPA, Djiappi-Tchamen B, Nana-Ndjangwo SM, Nchoutpouen E, Cornel AJ, Awono-Ambene P, Parola P, Tchuinkam T, Antonio-Nkondjio C
Parasit Vectors. 2021 Oct 11;14(1):527

The expansion of mosquito-borne diseases such as dengue, yellow fever, and chikungunya in the past 15 years has ignited the need for active surveillance of common and neglected mosquito-borne infectious diseases. The surveillance should be designed to detect diseases and to provide relevant field-based data for developing and implementing effective control measures to prevent outbreaks before significant public health consequences can occur.

Not Open Access | A population genetic perspective on the origin, spread and adaptation of the human malaria agents Plasmodium falciparum and Plasmodium vivax

September 25, 2021 - 12:04 -- NOT Open Access
Rougeron V, Boundenga L, Arnathau C, Durand P, Renaud F, Prugnolle F.
FEMS Microbiol Rev. 2021 Sep 22:fuab047

Malaria is considered one of the most important scourges that humanity has faced during its history, being responsible every year for numerous deaths worldwide. The disease is caused by protozoan parasites, among which two species are responsible of the majority of the burden, Plasmodium falciparum and Plasmodium vivax. For these two parasite species, the questions of their origin (how and when they appeared in humans), of their spread throughout the world, as well as how they have adapted to humans have long been of interest to the scientific community.

Biomarkers of cellular aging during a controlled human malaria infection

September 23, 2021 - 10:24 -- Open Access
Miglar A, Reuling IJ, Yap XZ, Färnert A, Sauerwein RW, Asghar M
Sci Rep. 2021 Sep 21;11(1):18733

Cellular aging is difficult to study in individuals with natural infection, given the diversity of symptom duration and clinical presentation, and the high interference of aging-related processes with host and environmental factors.

NOT Open Access | Single-genome sequencing reveals within-host evolution of human malaria parasites

September 8, 2021 - 17:05 -- NOT Open Access
Dia A, Jett C, Trevino SG, Chu CS, Sriprawat K, Anderson TJC, Nosten F, Cheeseman IH
Cell Host Microbe. 2021 Sep 1:S1931-3128(21)00385-1

Population genomics of bulk malaria infections is unable to examine intrahost evolution; therefore, most work has focused on the role of recombination in generating genetic variation. We used single-cell sequencing protocol for low-parasitaemia infections to generate 406 near-complete single Plasmodium vivax genomes from 11 patients sampled during sequential febrile episodes.

High incidence of Plasmodium knowlesi malaria compared to other human malaria species in several hospitals in Malaysia

September 1, 2021 - 17:35 -- Open Access
Lai MY, Rafieqin N, Lau YL, et al.
Trop Biomed. 2021 Sep 1;38(3):248-253

Through the regional control programme, Malaysia has been successfully reducing the incidence of Plasmodium falciparum and Plasmodium vivax infections. However, the incidence of zoonotic malaria Plasmodium knowlesi infection is increasing and now has been the major cause of malaria in Malaysia especially Malaysian Borneo. The emergence of knowlesi infection has threatened the malaria elimination programme which the government aims to reduce the overall malaria infections by 2020. Unlike other benign human Plasmodium spp., P. knowlesi can cause fatal infections.

Flowcytometric and ImageStream RNA-FISH gene expression, quantification and phenotypic characterization of blood and liver stages from human malaria species

September 1, 2021 - 16:22 -- Open Access
Luiza-Batista C, Nardella F, Thiberge S, Serra-Hassoun M, Ferreira MU, Scherf A, Garcia S
J Infect Dis. 2021 Aug 28:jiab431

We adapted the RNA FISH stellaris® method to specifically detect the expression of Plasmodium genes by flowcytometry and ImageStream (FlowFISH). This new method accurately quantified the erythrocytic forms of P. falciparum and vivax, and the sexual stages of P. vivax from patient isolates.

Simplified binomial estimation of human malaria transmission exposure distributions based on hard classification of where and when mosquitoes are caught: statistical applications with off-the-shelf tools

August 4, 2021 - 15:29 -- Open Access
Killeen GF, Monroe A, Govella NJ
Parasit Vectors. 2021 Aug 3;14(1):384

The impacts and limitations of personal protection measures against exposure to vectors of malaria and other mosquito-borne pathogens depend on behavioural interactions between humans and mosquitoes. Therefore, understanding where and when they overlap in time and space is critical. Commonly used approaches for calculating behaviour-adjusted estimates of human exposure distribution deliberately use soft classification of where and when people spend their time, to yield nuanced and representative distributions of mean exposure to mosquito bites across entire human populations or population groups.

Reducing mosquito-borne disease transmission to humans: A systematic review of cluster randomised controlled studies that assess interventions other than non-targeted insecticide

August 3, 2021 - 17:35 -- Open Access
Oliver J, Larsen S, Stinear TP, Hoffmann A, Crouch S, Gibney KB
PLoS Negl Trop Dis. 2021 Jul 29;15(7):e0009601

Mosquito control interventions are widely used to reduce mosquito-borne diseases. It is unclear what combination of interventions are most effective in reducing human disease. A novel intervention study for Buruli ulcer targeting mosquito vectors was proposed for a Buruli ulcer-endemic area of Victoria, Australia. The local community expressed a preference for avoiding widespread residual spraying of pyrethroids. To inform the design of a future cluster randomised control study (cRCT) for Buruli ulcer prevention in Victoria, we conducted a systematic literature review.


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