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malaria; plasmodium; falciparum; diagnostic; saliva

A saliva-based rapid test to quantify the infectious subclinical malaria parasite reservoir

January 10, 2019 - 15:53 -- Open Access
Dingyin Tao, Brent McGill, Timothy Hamerly, Tamaki Kobayashi, Prachi Khare, Amanda Dziedzic, Tomasz Leski, Andrew Holtz, Bruce Shull, Anne E. Jedlicka, Andrew Walzer, Paul D. Slowey, Christopher C. Slowey, Sandrine E. Nsango, David A. Stenger, Mike Chaponda, Modest Mulenga, Kathryn H. Jacobsen, David J. Sullivan, Sadie J. Ryan, Rashid Ansumana, William J. Moss, Isabelle Morlais and Rhoel R. Dinglasan
Science Translational Medicine 02 Jan 2019: Vol. 11, Issue 473, eaan4479

The gametocyte sexual form of Plasmodium falciparum, a parasite that causes human malaria, is responsible for mosquito-borne transmission of infection. Some individuals carry low concentrations of the parasite (subclinical infection), which makes detection and eradication difficult. Tao et al. developed a rapid lateral flow assay that detects a female gametocyte-specific protein, PSSP17, in saliva. 

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