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pre-erythrocytic stages

Optimization of an in vivo model to study immunity to Plasmodium falciparum pre-erythrocytic stages

December 23, 2019 - 15:05 -- Open Access
Author(s): 
Yevel Flores-Garcia, Sonia M. Herrera, Hugo Jhun, Daniel W. Pérez-Ramos, C. Richter King, Emily Locke, Ramadevi Raghunandan and Fidel Zavala
Reference: 
Malaria Journal 2019 18:426, 18 December 2019

The circumsporozoite protein (CSP) of Plasmodium is a key surface antigen that induces antibodies and T-cells, conferring immune protection in animal models and humans. However, much of the work on CSP and immunity has been developed based on studies using rodent or non-human primate CSP antigens, which may not be entirely translatable to CSP expressed by human malaria parasites, especially considering the host specificity of the different species.

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