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Recovery and stable persistence of chloroquine sensitivity in Plasmodium falciparum parasites after its discontinued use in Northern Uganda

February 22, 2020 - 16:49 -- Open Access
Betty Balikagala, Miki Sakurai-Yatsushiro, Shin-Ichiro Tachibana, Mie Ikeda, Masato Yamauchi, Osbert T. Katuro, Edward H. Ntege, Makoto Sekihara, Naoyuki Fukuda, Nobuyuki Takahashi, Shouki Yatsushiro, Toshiyuki Mori, Makoto Hirai, Walter Opio, Paul S. Obwoya, Denis A. Anywar, Mary A. Auma, Nirianne M. Q. Palacpac, Takafumi Tsuboi, Emmanuel I. Odongo-Aginya, Eisaku Kimura, Martin Ogwang, Toshihiro Horii & Toshihiro Mita
Malaria Journal 2020 19:76, 18 February 2020

Usage of chloroquine was discontinued from the treatment of Plasmodium falciparum infection in almost all endemic regions because of global spread of resistant parasites. Since the first report in Malawi, numerous epidemiological studies have demonstrated that the discontinuance led to re‑emergence of chloroquine‑susceptible P. falciparum, suggesting a possible role in future malaria control. However, most studies were cross‑sectional, with few studies looking at the persistence of chloroquine recovery in long term. This study fills the gap by providing, for a period of at least 6 years, proof of persistent re‑emergence/stable recovery of susceptible parasite populations using both molecular and phenotypic methods.

NOT Open Access | Risk factors for Burkitt lymphoma in East African children and minors: A case-control study in malaria-endemic regions in Uganda, Tanzania and Kenya

February 22, 2020 - 16:29 -- NOT Open Access
Peprah S, Ogwang MD, Kerchan P, Reynolds SJ, Tenge CN, Were PA, Kuremu RT, Wekesa WN, Sumba PO, Masalu N, Kawira E, Magatti J, Kinyera T, Otim I, Legason ID, Nabalende H, Dhudha H, Ally H, Genga IO, Mumia M, Ayers LW, Pfeiffer RM, Biggar RJ, Bhatia K, Goedert JJ, Mbulaiteye SM
Int J Cancer. 2020 Feb 15;146(4):953-969

Endemic Burkitt lymphoma (eBL) is the most common childhood cancer in sub‐Saharan African countries, however, few epidemiologic studies have been undertaken and none attempted enrolling cases from multiple countries. We therefore conducted a population‐based case–control study of eBL in children aged 0–15 years old in six regions in Northern Uganda, Northern Tanzania and Western Kenya, enrolling 862 suspected cases and 2,934 population controls (response rates 98.5–100%), and processing ~40,000 vials of samples using standardized protocols.

Healthcare professionals’ perspective can guide post-marketing surveillance of artemisinin-based combination therapy in Uganda

February 14, 2020 - 16:29 -- Open Access
Helen Byomire Ndagije, Ronald Kiguba, Niko Speybroeck, et al.
Malaria Journal 2020 19:63, 10 February 2020

Efficient testing to identify poor quality artemisinin-based combination therapy (ACT) is important to optimize efforts to control and eliminate malaria. Healthcare professionals interact with both ACT and malaria patients they treat and hence could observe, first-hand, suspect poor quality artemisinin-based combinations linked to poor malaria treatment outcomes and the factors associated with inappropriate use or treatment failure.

Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study

January 20, 2020 - 15:27 -- Open Access
Elijah Kakande, Bryan Greenhouse, Isabel Rodriguez-Barraquer, et al.
Malaria Journal 2020 19:21, 15 January 2020

Multiple red blood cell (RBC) variants appear to offer protection against the most severe forms of Plasmodium falciparum malaria. Associations between these variants and uncomplicated malaria are less clear.

Impact of vector control interventions on malaria transmission intensity, outdoor vector biting rates and Anopheles mosquito species composition in Tororo, Uganda

December 30, 2019 - 15:11 -- Open Access
Alex K. Musiime, David L. Smith, James P. Egonyu, et al.
Malaria Journal 2019 18:445, 27 December 2019

Long-lasting insecticidal nets (LLINs) and indoor residual spraying of insecticide (IRS) are widely recommended for the prevention of malaria in endemic regions. Data from human landing catches provide information on the impact of vector control on vector populations. Here, malaria transmission indoors and outdoors, before and after mass deployment of LLINs and IRS in Uganda was compared.

NOT Open Access | Anemia and transfusion requirements among Ugandan children with severe malaria treated with intravenous artesunate

December 23, 2019 - 14:23 -- NOT Open Access
Hawkes MT, Opoka RO, Conroy AL, Elphinstone RE, Hume HA, Namasopo S, Kain KC
Pediatr Hematol Oncol. 2019 Dec 12:1-13

Parenteral artesunate for the treatment of severe malaria in non-immune travelers is associated with late-onset hemolysis. In children in sub-Saharan Africa, the hematologic effects of malaria and artesunate are less well documented. Here we report a prospective case series of 91 children with severe malaria treated with parenteral artesunate, managed at a resource-poor hospital in Africa, with longitudinal data on hemoglobin (Hb), lactate dehydrogenase (LDH), haptoglobin, and erythrocyte morphology.


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