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NOT Open Access | Associations between aminoquinoline resistance genotypes and clinical presentations of Plasmodium falciparum infection in Uganda

July 14, 2020 - 15:58 -- NOT Open Access
Cuu G, Asua V, Tukwasibwe S, Nsobya S, Mpimbaza A, Rosenthal PJ
Antimicrob Agents Chemother. 2020 Jul 13:AAC.00721-20

Mutations that mediate resistance of Plasmodium falciparum to aminoquinoline antimalarials are selected by prior drug use and may alter parasite fitness, but associations with clinical presentations are uncertain. We evaluated genotypes in samples from a case control study of determinants of severe malaria in Ugandan children 4 months to 10 years of age. We studied 274 cases with severe malaria matched by age and geography to 275 uncomplicated malaria controls and 179 asymptomatic parasitemic controls.

The age-specific incidence of hospitalized paediatric malaria in Uganda

July 14, 2020 - 15:52 -- Open Access
Mpimbaza A, Walemwa R, Snow RW, et al.
BMC Infect Dis. 2020 Jul 13; 20(1):503

Understanding the relationship between malaria infection risk and disease outcomes represents a fundamental component of morbidity and mortality burden estimations. Contemporary data on severe malaria risks among populations of different parasite exposures are scarce. Using surveillance data, we compared rates of paediatric malaria hospitalisation in areas of varying parasite exposure levels.

NOT Open Access | Using the Ultrasensitive Alere Plasmodium falciparum Malaria Ag HRP-2(™) Rapid Diagnostic Test in the Field and Clinic in Northeastern Uganda

July 1, 2020 - 16:31 -- NOT Open Access
Owalla TJ, Okurut E, Apungia G, Ojakol B, Lema J, Sean MC, Thomas EG
Am J Trop Med Hyg. 2020 Jun 29

The ultrasensitive Alere Plasmodium falciparum Malaria Ag histidine-rich protein 2 rapid diagnostic test (Alere uRDT) is a new diagnostic tool which is more expensive than other malaria rapid diagnostic tests (RDTs) routinely used in Ugandan clinics. The manufacturer recommends testing samples within 2 days and scoring results after 20 minutes, which may be impractical in high-volume resource-poor clinics.

Identification and characterization of immature Anopheles and culicines (Diptera: Culicidae) at three sites of varying malaria transmission intensities in Uganda

June 26, 2020 - 11:04 -- Open Access
Alex K. Musiime, David L. Smith, Steve W. Lindsay, et al.
Malaria Journal 2020 19:221, 23 June 2020

Over the last two decades, there has been remarkable progress in malaria control in sub-Saharan Africa, due mainly to the massive deployment of long-lasting insecticidal nets and indoor residual spraying. Despite these gains, it is clear that in many situations, additional interventions are needed to further reduce malaria transmission. The World Health Organization (WHO) has promoted the Integrated Vector Management (IVM) approach through its Global Vector Control Response 2017–2030. However, prior roll-out of larval source management (LSM) as part of IVM, knowledge on ecology of larval aquatic habitats is required.

The Impact of Control Interventions on Malaria Burden in Young Children in a Historically High-Transmission District of Uganda: A Pooled Analysis of Cohort Studies from 2007 to 2018

May 21, 2020 - 06:46 -- Open Access
Kamya MR, Kakuru A, Dorsey G, et al.
Am J Trop Med Hyg. 2020 May 18

There is limited evidence on whether malaria elimination is feasible in high-transmission areas of Africa. Between 2007 and 2018, we measured the impact of malaria control interventions in young children enrolled in three clinical trials and two observational studies in Tororo, Uganda, a historically high-transmission area. Data were pooled from children aged 0.5–2 years.

NOT Open Access | Mean platelet counts are relatively decreased with malaria but relatively increased with endemic Burkitt Lymphoma in Uganda, Tanzania, and Kenya

May 13, 2020 - 14:54 -- NOT Open Access
Peprah S, Ogwang MD, Mbulaiteye SM, et al.
Br J Haematol. 2020 May 12

Platelet counts are decreased in Plasmodium falciparum malaria, which is aetiologically linked with endemic Burkitt lymphoma (eBL). However, the pattern of platelet counts in eBL cases is unknown. We studied platelet counts in 582 eBL cases and 2 248 controls enrolled in a case‐control study in Uganda, Tanzania and Kenya (2010–2016). Mean platelet counts in controls or eBL cases with or without malaria‐infection in controls versus eBLcases were compared using Student’s t‐test.

Effect of long-lasting insecticidal nets with and without piperonyl butoxide on malaria indicators in Uganda (LLINEUP): a pragmatic, cluster-randomised trial embedded in a national LLIN distribution campaign

April 20, 2020 - 09:38 -- Open Access
Staedke SG, Gonahasa S, Donnelly MJ, et al.
Lancet. 2020 Apr 18;395(10232):1292-1303

Long-lasting insecticidal nets (LLINs) are the primary malaria prevention tool, but their effectiveness is threatened by pyrethroid resistance. We embedded a pragmatic cluster-randomised trial into Uganda’s national LLIN campaign to compare conventional LLINs with those containing piperonyl butoxide (PBO), a synergist that can partially restore pyrethroid susceptibility in mosquito vectors.

Correlates of uptake of optimal doses of sulfadoxine-pyrimethamine for prevention of malaria during pregnancy in East-Central Uganda

April 18, 2020 - 13:55 -- Open Access
Mbonye K. Martin, Kirwana B. Venantius, Ndugga Patricia, Kikaire Bernard, Baleeta Keith, Kabagenyi Allen, Asiimwe Godfrey, Twesigye Rogers, Kadengye T. Damazo and Byonanebye M. Dathan
Malaria Journal 2020 19:153, 15 April 2020

In 2012, the World Health Organization recommended that pregnant women in malaria-endemic countries complete at least three (optimal) doses of intermittent preventive treatment (IPTp) using sulfadoxine-pyrimethamine (SP) to prevent malaria and related adverse events during pregnancy. Uganda adopted this recommendation, but uptake remains low in East-Central and information to explain this low uptake remains scanty. This analysis determined correlates of uptake of optimal doses of IPTp-SP in East-Central Uganda.

NOT Open Access | Relationships between measures of malaria at delivery and adverse birth outcomes in a high-transmission area of Uganda

April 10, 2020 - 16:39 -- NOT Open Access
Ategeka J, Kakuru A, Kajubi R, Wasswa R, Ochokoru H, Arinaitwe E, Adoke Y, Jagannathan P, R Kamya M, Muehlenbachs A, Chico RM, Dorsey G
J Infect Dis. 2020 Apr 2. pii: jiaa156

Clinical trials of interventions for preventing malaria in pregnancy often use measures of malaria at delivery as their primary outcome. Although the objective of these interventions is to improve birth outcomes, data on associations between different measures of malaria at delivery and adverse birth outcomes are limited.

Rapid shifts in the age-specific burden of malaria following successful control interventions in four regions of Uganda

March 31, 2020 - 15:30 -- Open Access
Simon P. Kigozi, Ruth N. Kigozi, Isabel Rodriguez-Barraquer, et al.
Malaria Journal 2020 19:128, 30 March 2020

Malaria control using long-lasting insecticidal nets (LLINs) and indoor residual spraying of insecticide (IRS) has been associated with reduced transmission throughout Africa. However, the impact of transmission reduction on the age distribution of malaria cases remains unclear.


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