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Uganda

NOT Open Access | Comparison of capillary versus venous blood for the diagnosis of Plasmodium falciparum malaria using rapid diagnostic tests

January 31, 2021 - 15:45 -- NOT Open Access
Author(s): 
Gorret AM, Muhindo R, Baguma E, Ntaro M, Mulogo EM, Deutsch-Feldman M, Juliano JJ, Nyehangane D, Boyce RM
Reference: 
J Infect Dis. 2021 Jan 27:jiab032

We enrolled 250 febrile children in western Uganda to compare the results of malaria rapid diagnostic tests when using capillary versus venous blood. Participants were tested with four different RDT types. PCR testing was performed as the reference standard. Sensitivity and specificity were broadly similar across RDT types and sampling method.

A longitudinal study of plasma BAFF levels in mothers and their infants in Uganda, and correlations with subsets of B cells

January 20, 2021 - 07:03 -- Open Access
Author(s): 
Rönnberg C, Lugaajju A, Nyman A, Hammar U, Bottai M, Lautenbach MJ, Sundling C, Kironde F, Persson KEM
Reference: 
PLoS One. 2021 Jan 19;16(1):e0245431

Malaria is a potentially life-threatening disease with approximately half of the world's population at risk. Young children and pregnant women are hit hardest by the disease. B cells and antibodies are part of an adaptive immune response protecting individuals continuously exposed to the parasite. An infection with Plasmodium falciparum can cause dysregulation of B cell homeostasis, while antibodies are known to be key in controlling symptoms and parasitemia. BAFF is an instrumental cytokine for the development and maintenance of B cells.

Relationships between test positivity rate, total laboratory confirmed cases of malaria, and malaria incidence in high burden settings of Uganda: an ecological analysis

January 13, 2021 - 14:16 -- Open Access
Author(s): 
Jaffer Okiring, Adrienne Epstein, Grant Dorsey, et al.
Reference: 
Malaria Journal 2021 20:42, 13 January 2021

Malaria surveillance is critical for monitoring changes in malaria morbidity over time. National Malaria Control Programmes often rely on surrogate measures of malaria incidence, including the test positivity rate (TPR) and total laboratory confirmed cases of malaria (TCM), to monitor trends in malaria morbidity. However, there are limited data on the accuracy of TPR and TCM for predicting temporal changes in malaria incidence, especially in high burden settings.

Plasma angiopoietin-2 is associated with age-related deficits in cognitive sub-scales in Ugandan children following severe malaria

January 9, 2021 - 13:14 -- Open Access
Author(s): 
Benson J. Ouma, Paul Bangirana, John M. Ssenkusu, Dibyadyuti Datta, Robert O. Opoka, Richard Idro, Kevin C. Kain, Chandy C. John and Andrea L. Conroy
Reference: 
Malaria Journal 2021 20:17, 6 January 2021

Elevated angiopoietin-2 (Angpt-2) concentrations are associated with worse overall neurocognitive function in severe malaria survivors, but the specific domains affected have not been elucidated.

Determinants of uptake of malaria preventive interventions among pregnant women in eastern Uganda

January 6, 2021 - 11:43 -- Open Access
Author(s): 
Solomon Tsebeni Wafula, Hilbert Mendoza, Aisha Nalugya, David Musoke and Peter Waiswa
Reference: 
Malaria Journal 2021 20:5, 3 January 2021

Consistent use of insecticide-treated nets (ITNs) and intermittent preventive treatment in pregnancy (IPTp) have been recommended as cost-effective interventions for malaria prevention during pregnancy in endemic areas. However, the coverage and utilization of these interventions during pregnancy in sub-Saharan Africa is still suboptimal. This study aimed to determine the uptake of IPTp and ITNs and associated factors among women during their recent pregnancy in Eastern Uganda.

Deletions of pfhrp2 and pfhrp3 genes were uncommon in rapid diagnostic test-negative Plasmodium falciparum isolates from Uganda

January 6, 2021 - 11:42 -- Open Access
Author(s): 
Sam L. Nsobya, Andrew Walakira, Philip J. Rosenthal, et al.
Reference: 
Malaria Journal 2021 20:4, 2 January 2021

Rapid diagnostic tests (RDTs) play a key role in malaria case management. The most widely used RDT identifies Plasmodium falciparum based on immunochromatographic recognition of P. falciparum histidine-rich protein 2 (PfHRP2). Deletion of the paralogous pfhrp2 and pfhrp3 genes leads to false-negative PfHRP2-based RDTs, and has been reported in P. falciparum infections from South America and Africa. However, identification of pfhrp2/pfhrp3 deletions has usually been based only on failure to amplify these genes using PCR, without confirmation based on PfHRP2 protein expression, and understanding of the true prevalence of deletions is incomplete.

Limitations of rapid diagnostic tests in malaria surveys in areas with varied transmission intensity in Uganda 2017-2019: Implications for selection and use of HRP2 RDTs

January 6, 2021 - 11:34 -- Open Access
Author(s): 
Bosco AB, Nankabirwa JI, Kamya MR, et al.
Reference: 
PLoS One. 2020 Dec 31;15(12):e0244457

Plasmodium falciparum histidine-rich protein 2 (HRP2)-based rapid diagnostic tests (RDTs) are exclusively recommended for malaria diagnosis in Uganda; however, their functionality can be affected by parasite-related factors that have not been investigated in field settings.

Ex vivo susceptibility of Plasmodium falciparum to antimalarial drugs in Northern Uganda

December 30, 2020 - 13:30 -- Open Access
Author(s): 
Fukuda N, Tachibana SI, Mita T, et al.
Reference: 
Parasitol Int. 2020 Dec 25:102277

In Uganda, artemether-lumefantrine was introduced as an artemisinin-based combination therapy (ACT) for malaria in 2006. We have previously reported a moderate decrease in ex vivo efficacy of lumefantrine in Northern Uganda, where we also detected ex vivo artemisinin-resistant Plasmodium falciparum. Therefore, it is necessary to search for candidate partner alternatives for ACT.

Spatial-temporal patterns of malaria incidence in Uganda using HMIS data from 2015 to 2019

December 16, 2020 - 09:54 -- Open Access
Author(s): 
Kigozi SP, Kigozi RN, Sebuguzi CM, Cano J, Rutazaana D, Opigo J, Bousema T, Yeka A, Gasasira A, Sartorius B, Pullan RL
Reference: 
BMC Public Health. 2020 Dec 14;20(1):1913

As global progress to reduce malaria transmission continues, it is increasingly important to track changes in malaria incidence rather than prevalence. Risk estimates for Africa have largely underutilized available health management information systems (HMIS) data to monitor trends. This study uses national HMIS data, together with environmental and geographical data, to assess spatial-temporal patterns of malaria incidence at facility catchment level in Uganda, over a recent 5-year period.

Non-adherence to long-lasting insecticide treated bednet use following successful malaria control in Tororo, Uganda

December 8, 2020 - 10:44 -- Open Access
Author(s): 
Rek J, Musiime A, Zedi M, Otto G, Kyagamba P, Asiimwe Rwatooro J, Arinaitwe E, Nankabirwa J, Staedke SG, Drakeley C, Rosenthal PJ, Kamya M, Dorsey G, Krezanoski PJ
Reference: 
PLoS One. 2020 Dec 3;15(12):e0243303

Indoor residual spraying (IRS) and long-lasting insecticide-treated bednets (LLINs) are common tools for reducing malaria transmission. We studied a cohort in Uganda with universal access to LLINs after 5 years of sustained IRS to explore LLIN adherence when malaria transmission has been greatly reduced. Eighty households and 526 individuals in Nagongera, Uganda were followed from October 2017 -October 2019. Every two weeks, mosquitoes were collected from sleeping rooms and LLIN adherence the prior night assessed. Episodes of malaria were diagnosed using passive surveillance.

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