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antibody responses

Acquired antibody responses against merozoite surface protein-1(19) antigen during Plasmodium falciparum and P.vivax infections in South Indian city of Mangaluru

October 31, 2020 - 09:30 -- Open Access
Author(s): 
Punnath K, Dayanand KK, Midya V, Chandrashekar VN, Achur RN, Kakkilaya SB, Ghosh SK, Kumari SN, Gowda DC
Reference: 
J Parasit Dis. 2020 Oct 21:1-1

Merozoite surface protein-1 (MSP-1) of malaria parasites has been extensively studied as a malaria vaccine candidate and the antibody response to this protein is an important indicator of protective immunity to malaria. Mangaluru city and its surrounding areas in southwestern India are endemic to malaria with Plasmodium vivax being the most widespread and prevalent species although P. falciparum also frequently infects.

Microarray analyses reveal strain-specific antibody responses to Plasmodium falciparum apical membrane antigen 1 variants following natural infection and vaccination

March 9, 2020 - 15:03 -- Open Access
Author(s): 
Bailey JA, Berry AA, Plowe CV, et al.
Reference: 
Sci Rep. 2020 Mar 3;10(1):3952

Vaccines based on Plasmodium falciparum apical membrane antigen 1 (AMA1) have failed due to extensive polymorphism in AMA1. To assess the strain-specificity of antibody responses to malaria infection and AMA1 vaccination, we designed protein and peptide microarrays representing hundreds of unique AMA1 variants. Following clinical malaria episodes, children had short-lived, sequence-independent increases in average whole-protein seroreactivity, as well as strain-specific responses to peptides representing diverse epitopes.

Pattern of antibody responses to Plasmodium falciparum antigens in individuals differentially exposed to Anopheles bites

February 25, 2020 - 15:54 -- Open Access
Author(s): 
Kakou G. Aka, Dipomin F. Traoré, André B. Sagna, Dounin D. Zoh, Serge B. Assi, Bertin N’cho Tchiekoi, Akré M. Adja, Franck Remoue and Anne Poinsignon
Reference: 
Malaria Journal 2020 19:83, 21 February 2020

In malaria-endemic areas, human populations are frequently exposed to immunomodulatory salivary components injected during mosquito blood feeding. The consequences on pathogen-specific immune responses are not well known. This study evaluated and compared the humoral responses specific to merozoite stage vaccine candidates of Plasmodium falciparum, in children differentially exposed to Anopheles bites in a natural setting.

Not Open Access | Schistosoma haematobium infection modulates Plasmodium falciparum parasite density and antimalarial antibody responses

February 14, 2020 - 17:07 -- NOT Open Access
Author(s): 
Tokplonou L, Nouatin O, Courtin D, et al.
Reference: 
Parasite Immunol. 2020 Feb 5:e12702

Schistosomiasis and malaria are endemic in sub‐Saharan Africa where Schistosoma haematobium (Sh) and Plasmodium falciparum (Pf) coinfections are thus frequent. We explored the effect of Sh infection on antibody responses directed to Pf merozoite antigens and on malaria susceptibility in Beninese children.

Antibody responses within two leading Plasmodium vivax vaccine candidate antigens in three geographically diverse malaria-endemic regions of India

December 17, 2019 - 16:49 -- Open Access
Author(s): 
Sonal Kale, Chander P. Yadav, Prashant K. Mallick, et al.
Reference: 
Malaria Journal 2019 18:425, 16 December 2019

Identifying highly immunogenic blood stage antigens which can work as target for naturally acquired antibodies in different eco-epidemiological settings is an important step for designing malaria vaccine. Blood stage proteins of Plasmodium vivax, apical membrane antigen-1 (PvAMA-1) and 19 kDa fragment of merozoite surface protein (PvMSP-119) are such promising vaccine candidate antigens. This study determined the naturally-acquired antibody response to PvAMA-1 and PvMSP-119 antigens in individuals living in three geographically diverse malaria endemic regions of India.

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