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NOT Open Access | Pharmacogene sequencing of a Gabonese population with severe Plasmodium falciparum malaria reveals multiple novel variants with putative relevance for antimalarial treatment

April 22, 2021 - 08:24 -- NOT Open Access
Pernaute-Lau L, Adegnika AA, Zhou Y, Zinsou JF, Gil JP, Krishna S, Kremsner PG, Lauschke VM, Velavan TP
Antimicrob Agents Chemother. 2021 Apr 19:AAC.00275-21

Malaria remains one of the most deadly diseases in Africa, particularly for children. While successful in reducing morbidity and mortality, antimalarial treatments are also a major cause of adverse drug reactions (ADRs). Host genetic variation in genes involved in drug disposition or toxicity constitutes an important determinant of ADR risk and can prime for parasite drug resistance. Importantly however, the genetic diversity in Africa is substantial and thus genetic profiles in one population cannot be reliably extrapolated to other ethnogeographic groups.

Malaria in children and women of childbearing age: infection prevalence, knowledge and use of malaria prevention tools in the province of Nyanga, Gabon

November 4, 2020 - 10:00 -- Open Access
Roméo Karl Imboumy-Limoukou, Sydney Maghendji-Nzondo, Jean-Bernard Lekana-Douki, et al.
Malaria Journal 2020 19:387, 2 November 2020

There is little information on the social perception of malaria and the use of preventative measures in Gabon, especially in rural areas. Adequate knowledge of malaria prevention and control can help in reducing the burden of malaria among vulnerable groups, particularly pregnant women and children under 5 years old living in malaria-endemic settings. This study was designed to assess the prevalence of malaria and the knowledge and attitude towards this disease in households in Nyanga Province.

Comparative performance of four malaria rapid diagnostic tests, Vikia Malaria Pf/Pan, Meriline-Meriscreen Pf/Pv/Pan, Right Sign Malaria Pf/Pan, and Right Sign Malaria Pf, among febrile patients in Gabon

June 26, 2020 - 12:02 -- Open Access
Ditombi BCM, Minko JI, Tsamba RP, Ngomo JMN, Nymane T, Ognagosso FBB, M'bondoukwe NP, Mawili-Mboumba DP, Akotet MKB
Rev Soc Bras Med Trop. 2020 Jun 22; 53:e20190274

Rapid diagnostic tests (RDTs) are selected based on their performances. Here, we compared the diagnostic performance of different malaria RDTs.

Identification of a conserved var gene in different Plasmodium falciparum strains

June 2, 2020 - 09:29 -- Open Access
Sandra Dimonte, Ellen I. Bruske, Corinna Enderes, Thomas D. Otto, Louise Turner, Peter Kremsner and Matthias Frank
Malaria Journal 2020 19:194, 29 May 2020

The multicopy var gene family of Plasmodium falciparum is of crucial importance for pathogenesis and antigenic variation. So far only var2csa, the var gene responsible for placental malaria, was found to be highly conserved among all P. falciparum strains. Here, a new conserved 3D7 var gene (PF3D7_0617400) is identified in several field isolates.

NOT Open Access | IgG antibody response against Plasmodium falciparum Aminopeptidase 1 antigen in Gabonese children living in Makokou and Franceville

February 16, 2020 - 09:20 -- NOT Open Access
Lydie Oyegue-Liabagui S, Imboumy-Limoukou RK, Kouna CL, Bangueboussa F, Schmitt M, Florent I, Bernard Lekana-Douki J
Clin Exp Immunol. 2020 Feb 6

The search for novel chemical classes of anti‐malarial compounds to cope with the current state of chemoresistance of malaria parasites, led to the identification of PfA‐M1 as a new therapeutic target. PfA‐M1, known to be involved in the hemoglobin digestion cascade which helps to provide most of the amino acids necessary to the parasite’s metabolism, is currently considered as a promising target for anti‐malarial chemotherapy.

Exposure to Ebola Virus and Risk for Infection with Malaria Parasites, Rural Gabon

February 10, 2020 - 16:22 -- Open Access
Jessica L. Abbate, Pierre Becquart, Eric Leroy, Vanessa O. Ezenwa, Benjamin Roche
Emerging Infectious Diseases, Volume 26, Volume 26, Number 2—February 2020

An association between malaria and risk for death among patients with Ebola virus disease has suggested within-host interactions between Plasmodium falciparum parasites and Ebola virus. To determine whether such an interaction might also influence the probability of acquiring either infection, we used a large snapshot surveillance study from rural Gabon to test if past exposure to Ebola virus is associated with current infection with Plasmodium spp. during nonepidemic conditions.

NOT Open Access | High Circulation of Malaria and Low Prevalence of Bacteremia in Febrile and Afebrile Children in Northeastern Gabon

January 20, 2020 - 14:35 -- NOT Open Access
Boumbanda Koyo CS, Oyegue-Liabagui SL, Mediannikov O, Cortaredona S, Kouna LC, Raoult D, Lekana-Douki JB, Fenollar F
The American Journal of Tropical Medicine and Hygiene, Volume 102, Issue 1, 8 Jan 2020, p. 121 - 129

The epidemiology of febrile illness etiologies is under-explored in resource-poor settings. Establishing a local repertory of microorganisms circulating in blood of febrile and afebrile people is important for physicians. Blood was collected from 428 febrile and 88 afebrile children in Makokou (Gabon) and analyzed using polymerase chain reaction. Plasmodium spp. were the pathogens, which were most detected in febrile children (69.6%; 298/428) and in afebrile children (31.8%; 28/88) (P < 0.0001).

Monitoring of efficacy, tolerability and safety of artemether–lumefantrine and artesunate–amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Lambaréné, Gabon: an open-label clinical trial

December 17, 2019 - 16:46 -- Open Access
Bayode R. Adegbite, Jean R. Edoa, Ayola A. Adegnika, et al.
Malaria Journal 2019 18:424, 16 December 2019

Malaria remains a major public health problem, affecting mainly low-and middle-income countries. The management of this parasitic disease is challenged by ever increasing drug resistance. This study, investigated the therapeutic efficacy, tolerability and safety of artemether–lumefantrine (AL) and artesunate–amodiaquine (AS–AQ), used as first-line drugs to treat uncomplicated malaria in Lambaréné, Gabon.

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