The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10611 malaria professionals are enjoying the free benefits of MalariaWorld today

Gabon

Comparative performance of four malaria rapid diagnostic tests, Vikia Malaria Pf/Pan, Meriline-Meriscreen Pf/Pv/Pan, Right Sign Malaria Pf/Pan, and Right Sign Malaria Pf, among febrile patients in Gabon

June 26, 2020 - 12:02 -- Open Access
Author(s): 
Ditombi BCM, Minko JI, Tsamba RP, Ngomo JMN, Nymane T, Ognagosso FBB, M'bondoukwe NP, Mawili-Mboumba DP, Akotet MKB
Reference: 
Rev Soc Bras Med Trop. 2020 Jun 22; 53:e20190274

Rapid diagnostic tests (RDTs) are selected based on their performances. Here, we compared the diagnostic performance of different malaria RDTs.

Identification of a conserved var gene in different Plasmodium falciparum strains

June 2, 2020 - 09:29 -- Open Access
Author(s): 
Sandra Dimonte, Ellen I. Bruske, Corinna Enderes, Thomas D. Otto, Louise Turner, Peter Kremsner and Matthias Frank
Reference: 
Malaria Journal 2020 19:194, 29 May 2020

The multicopy var gene family of Plasmodium falciparum is of crucial importance for pathogenesis and antigenic variation. So far only var2csa, the var gene responsible for placental malaria, was found to be highly conserved among all P. falciparum strains. Here, a new conserved 3D7 var gene (PF3D7_0617400) is identified in several field isolates.

NOT Open Access | IgG antibody response against Plasmodium falciparum Aminopeptidase 1 antigen in Gabonese children living in Makokou and Franceville

February 16, 2020 - 09:20 -- NOT Open Access
Author(s): 
Lydie Oyegue-Liabagui S, Imboumy-Limoukou RK, Kouna CL, Bangueboussa F, Schmitt M, Florent I, Bernard Lekana-Douki J
Reference: 
Clin Exp Immunol. 2020 Feb 6

The search for novel chemical classes of anti‐malarial compounds to cope with the current state of chemoresistance of malaria parasites, led to the identification of PfA‐M1 as a new therapeutic target. PfA‐M1, known to be involved in the hemoglobin digestion cascade which helps to provide most of the amino acids necessary to the parasite’s metabolism, is currently considered as a promising target for anti‐malarial chemotherapy.

Exposure to Ebola Virus and Risk for Infection with Malaria Parasites, Rural Gabon

February 10, 2020 - 16:22 -- Open Access
Author(s): 
Jessica L. Abbate, Pierre Becquart, Eric Leroy, Vanessa O. Ezenwa, Benjamin Roche
Reference: 
Emerging Infectious Diseases, Volume 26, Volume 26, Number 2—February 2020

An association between malaria and risk for death among patients with Ebola virus disease has suggested within-host interactions between Plasmodium falciparum parasites and Ebola virus. To determine whether such an interaction might also influence the probability of acquiring either infection, we used a large snapshot surveillance study from rural Gabon to test if past exposure to Ebola virus is associated with current infection with Plasmodium spp. during nonepidemic conditions.

NOT Open Access | High Circulation of Malaria and Low Prevalence of Bacteremia in Febrile and Afebrile Children in Northeastern Gabon

January 20, 2020 - 14:35 -- NOT Open Access
Author(s): 
Boumbanda Koyo CS, Oyegue-Liabagui SL, Mediannikov O, Cortaredona S, Kouna LC, Raoult D, Lekana-Douki JB, Fenollar F
Reference: 
The American Journal of Tropical Medicine and Hygiene, Volume 102, Issue 1, 8 Jan 2020, p. 121 - 129

The epidemiology of febrile illness etiologies is under-explored in resource-poor settings. Establishing a local repertory of microorganisms circulating in blood of febrile and afebrile people is important for physicians. Blood was collected from 428 febrile and 88 afebrile children in Makokou (Gabon) and analyzed using polymerase chain reaction. Plasmodium spp. were the pathogens, which were most detected in febrile children (69.6%; 298/428) and in afebrile children (31.8%; 28/88) (P < 0.0001).

Monitoring of efficacy, tolerability and safety of artemether–lumefantrine and artesunate–amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Lambaréné, Gabon: an open-label clinical trial

December 17, 2019 - 16:46 -- Open Access
Author(s): 
Bayode R. Adegbite, Jean R. Edoa, Ayola A. Adegnika, et al.
Reference: 
Malaria Journal 2019 18:424, 16 December 2019

Malaria remains a major public health problem, affecting mainly low-and middle-income countries. The management of this parasitic disease is challenged by ever increasing drug resistance. This study, investigated the therapeutic efficacy, tolerability and safety of artemether–lumefantrine (AL) and artesunate–amodiaquine (AS–AQ), used as first-line drugs to treat uncomplicated malaria in Lambaréné, Gabon.

Subscribe to RSS - Gabon