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Overabundance of Asaia and Serratia Bacteria Is Associated with Deltamethrin Insecticide Susceptibility in Anopheles coluzzii from Agboville, Côte d'Ivoire

November 3, 2021 - 20:25 -- Open Access
Pelloquin B, Kristan M, Edi C, Meiwald A, Clark E, Jeffries CL, Walker T, Dada N, Messenger LA
Microbiol Spectr. 2021 Oct 31;9(2):e0015721

Insecticide resistance among mosquito species is now a pervasive phenomenon that threatens to jeopardize global malaria vector control efforts. Evidence of links between the mosquito microbiota and insecticide resistance is emerging, with significant enrichment of insecticide degrading bacteria and enzymes in resistant populations. Using 16S rRNA amplicon sequencing, we characterized and compared the microbiota of Anopheles coluzzii in relation to their deltamethrin resistance and exposure profiles.

Intensity and mechanisms of deltamethrin and permethrin resistance in Anopheles gambiae s.l. populations in southern Benin

April 22, 2021 - 08:50 -- Open Access
Sagbohan HW, Kpanou CD, Akogbeto M, et al.
Parasit Vectors. 2021 Apr 14;14(1):202

Insecticide resistance is threatening the effectiveness of efforts to control malaria vectors in Benin. This study explores the levels and mechanisms of insecticide resistance in An. gambiae s.l. to pyrethroids.

Not Open Access | A deltamethrin crystal polymorph for more effective malaria control

October 14, 2020 - 12:31 -- NOT Open Access
Yang J, Erriah B, Hu CT, Reiter E, Zhu X, López-Mejías V, Carmona-Sepúlveda IP, Ward MD, Kahr B
Proc Natl Acad Sci U S A. 2020 Oct 12:202013390

Pyrethroid contact insecticides are mainstays of malaria control, but their efficacies are declining due to widespread insecticide resistance in Anopheles mosquito populations, a major public health challenge. Several strategies have been proposed to overcome this challenge, including insecticides with new modes of action. New insecticides, however, can be expensive to implement in low-income countries.

Efficacy of Fludora® Fusion (a mixture of deltamethrin and clothianidin) for indoor residual spraying against pyrethroid-resistant malaria vectors: laboratory and experimental hut evaluation

September 15, 2020 - 14:28 -- Open Access
Fongnikin A, Houeto N, Agbevo A, Odjo A, Syme T, N'Guessan R, Ngufor C
Parasit Vectors. 2020 Sep 11;13(1):466

A new generation of IRS insecticides which can provide improved and prolonged control of pyrethroid-resistant malaria vector populations are being developed. Fludora® Fusion is a new IRS insecticide containing a mixture of deltamethrin and clothianidin, a neonicotinoid.

'What I cannot create, I do not understand': functionally validated synergism of metabolic and target site insecticide resistance

May 27, 2020 - 10:39 -- Open Access
Samantsidis GR, Panteleri R, Denecke S, Kounadi S, Christou I, Nauen R, Douris V, Vontas J
Proc Biol Sci. 2020 May 27;287(1927):20200838

The putative synergistic action of target-site mutations and enhanced detoxification in pyrethroid resistance in insects has been hypothesized as a major evolutionary mechanism responsible for dramatic consequences in malaria incidence and crop production. Combining genetic transformation and CRISPR/Cas9 genome modification, we generated transgenic Drosophila lines expressing pyrethroid metabolizing P450 enzymes in a genetic background along with engineered mutations in the voltage-gated sodium channel (para) known to confer target-site resistance.

Characterization and monitoring of deltamethrin-resistance in Anopheles culicifacies in the presence of a long-lasting insecticide-treated net intervention

November 15, 2018 - 14:55 -- Open Access
Madhavinadha Prasad Kona, Raghavendra Kamaraju, Veena Pandey, et al.
Malaria Journal 2018 17:414

This field study, in a tribal district of India, after distribution of deltamethrin-impregnated LLINs showed decrease in deltamethrin susceptibility in An. culicifacies, a major vector of malaria in this study area and in India. Results indicated development of resistance as imminent with the increase in insecticide selection pressure. 

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