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deltamethrin

Not Open Access | A deltamethrin crystal polymorph for more effective malaria control

October 14, 2020 - 12:31 -- NOT Open Access
Author(s): 
Yang J, Erriah B, Hu CT, Reiter E, Zhu X, López-Mejías V, Carmona-Sepúlveda IP, Ward MD, Kahr B
Reference: 
Proc Natl Acad Sci U S A. 2020 Oct 12:202013390

Pyrethroid contact insecticides are mainstays of malaria control, but their efficacies are declining due to widespread insecticide resistance in Anopheles mosquito populations, a major public health challenge. Several strategies have been proposed to overcome this challenge, including insecticides with new modes of action. New insecticides, however, can be expensive to implement in low-income countries.

Efficacy of Fludora® Fusion (a mixture of deltamethrin and clothianidin) for indoor residual spraying against pyrethroid-resistant malaria vectors: laboratory and experimental hut evaluation

September 15, 2020 - 14:28 -- Open Access
Author(s): 
Fongnikin A, Houeto N, Agbevo A, Odjo A, Syme T, N'Guessan R, Ngufor C
Reference: 
Parasit Vectors. 2020 Sep 11;13(1):466

A new generation of IRS insecticides which can provide improved and prolonged control of pyrethroid-resistant malaria vector populations are being developed. Fludora® Fusion is a new IRS insecticide containing a mixture of deltamethrin and clothianidin, a neonicotinoid.

'What I cannot create, I do not understand': functionally validated synergism of metabolic and target site insecticide resistance

May 27, 2020 - 10:39 -- Open Access
Author(s): 
Samantsidis GR, Panteleri R, Denecke S, Kounadi S, Christou I, Nauen R, Douris V, Vontas J
Reference: 
Proc Biol Sci. 2020 May 27;287(1927):20200838

The putative synergistic action of target-site mutations and enhanced detoxification in pyrethroid resistance in insects has been hypothesized as a major evolutionary mechanism responsible for dramatic consequences in malaria incidence and crop production. Combining genetic transformation and CRISPR/Cas9 genome modification, we generated transgenic Drosophila lines expressing pyrethroid metabolizing P450 enzymes in a genetic background along with engineered mutations in the voltage-gated sodium channel (para) known to confer target-site resistance.

Characterization and monitoring of deltamethrin-resistance in Anopheles culicifacies in the presence of a long-lasting insecticide-treated net intervention

November 15, 2018 - 14:55 -- Open Access
Author(s): 
Madhavinadha Prasad Kona, Raghavendra Kamaraju, Veena Pandey, et al.
Reference: 
Malaria Journal 2018 17:414

This field study, in a tribal district of India, after distribution of deltamethrin-impregnated LLINs showed decrease in deltamethrin susceptibility in An. culicifacies, a major vector of malaria in this study area and in India. Results indicated development of resistance as imminent with the increase in insecticide selection pressure. 

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