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sickle cell

Transfusion-Transmitted Malaria: Two Pediatric Cases From the United States and Their Relevance in an Increasingly Globalized World

September 29, 2021 - 10:08 -- Open Access
Stubbs LA, Price M, Noland D, Fuchs J, Filkins L, McElvania E, Luu HS, Sebert M, Waters A, Hsiang MS
J Pediatric Infect Dis Soc. 2021 Sep 24:piab083

In non-endemic settings, transfusion-transmitted malaria (TTM) is rare but potentially fatal and becoming more common with globalization.

Analysis of clinical presentation, hematological factors, self-reported bed net usage, and malaria burden in sickle cell disease patients

September 1, 2021 - 17:19 -- Open Access
Harp KO, Botchway F, Dei-Adomakoh Y, Wilson MD, Mubasher M, Adjei AA, Thompson WE, Stiles JK, Driss A
EClinicalMedicine. 2021 Jul 31;39:101045

Sickle cell anemia (SCA) is a severe monogenic disorder, caused by single nucleotide mutations in the hemoglobin (Hb) gene, that is prevalent in malaria endemic regions of the world. Sickle cell trait (SCT) individuals carry only one of the mutated alleles and were shown to be protected against malaria. However, defining the relative contribution of hematological, clinical, and environmental factors to the overall burden of malaria in individuals with hemoglobinopathies such as SCA has been challenging.

Haematological abnormalities in children with sickle cell disease and non-severe malaria infection in western Kenya

April 14, 2021 - 16:43 -- Open Access
Kosiyo P, Otieno W, Gitaka J, Munde EO, Ouma C
BMC Infect Dis. 2021 Apr 7;21(1):329Background

In Plasmodium falciparum infection, clinical conditions such as anaemia, thrombocytopenia and leukocytosis are common. Mutation in haemoglobin sub-unit beta gene (HBB) may be a genetic factor responsible for these haematological changes during infection. However, the contributions of the carriage of different HBB genotypes on these changes remain largely unknown.

Age-related Changes in Malaria Clinical Phenotypes During Infancy are Modified by Sickle Cell Trait

March 23, 2021 - 14:47 -- Open Access
Zehner N, Adrama H, Jagannathan P, et al.
Clin Infect Dis. 2021 Mar 19:ciab245

Young infants are protected against Plasmodium falciparum malaria. Mechanisms driving this protection remain unclear due to a poor understanding of malaria clinical phenotypes during infancy.

Association between haematological parameters and sickle cell genotypes in children with Plasmodium falciparum malaria resident in Kisumu County in Western Kenya

November 28, 2020 - 15:53 -- Open Access
Kosiyo P, Otieno W, Gitaka J, Munde EO, Ouma C
BMC Infect Dis. 2020 Nov 25;20(1):887

Sickle cell disease (SCD) is a monogenic disorder due to point mutation in the β-globin gene resulting in substitution of Valine for Glutamic acid. The SCD is prevalent in P. falciparum endemic regions such as western Kenya. Carriage of different sickle cell genotypes may influence haematological parameter during malaria. Children resident in malaria holoendemic regions suffer more from malaria-related complications and this is moderated by the presence of the SCD. In the current study, we determined the association between sickle cell genotypes and haematological parameters in children with P. falciparum malaria resident in Kisumu County in Western Kenya.

Prevalence of sickle cell disorders and malaria infection in children aged 1–12 years in the Volta Region, Ghana: a community-based study

November 24, 2020 - 14:59 -- Open Access
Mavis Oppong, Helena Lamptey, Eric Kyei-Baafour, Belinda Aculley, Ebenezer Addo Ofori, Bernard Tornyigah, Margaret Kweku and Michael F. Ofori
Malaria Journal 2020 19:426, 23 November 2020

Alterations in the structure of haemoglobin (Hb) are usually brought about by point mutations affecting one or, in some cases, two codons encoding amino acids of the globin chains. One in three Ghanaians are said to have sickle cell disorders, whereas malaria continues to be one of the leading causes of mortality among children. This study determined the prevalence of sickle cell disorders and malaria infection among children aged 1–12 years in the Volta Region.

Sickle cell disease and malaria: decreased exposure and asplenia can modulate the risk from Plasmodium falciparum

April 27, 2020 - 13:24 -- Open Access
Richard O. Mwaiswelo, William Mawala, Per O. Iversen, Mariane de Montalembert, Lucio Luzzatto and Julie Makani
Malaria Journal 2020 19:165, 25 April 2020

Patients with sickle cell disease (SCD), an inherited haemoglobinopathy, have increased risk of malaria, at least in part due to impaired splenic function. Infection with Plasmodium falciparum in SCD patients can trigger painful vaso-occlusive crisis, increase the severity of anaemia, and contribute to early childhood mortality.

Utilization patterns of malaria chemoprophylaxis among Tanzanian children attending sickle cell clinic in Dar es Salaam tertiary hospitals

December 10, 2019 - 08:03 -- Open Access
Esther J. Ndegeulaya, George M. Bwire, Raphael Z. Sangeda, Doreen Mloka, Faustine Tungaraza, Augustino S. Kahere, Fidelis F. Manyaki, Fatuma F. Felician, Manase Kilonzi, Wigilya P. Mikomangwa, Hamu J. Mlyuka, Alphonce I. Marealle, Ritah Mutagonda, Liberata Mwita and Kennedy D. Mwambete
Malaria Journal 2019 18:393, 3 December 2019

Malaria is among the leading cause of infection in individuals with sickle cell disease (SCD) living in sub-Saharan Africa, including Tanzania. However, after 2005 the standard treatment guidelines (STGs) on malaria chemoprevention for SCD patients were non-existent, and at present no medicine is recommended for SCD patients. Since several anti-malarials have been approved for the treatment of malaria in Tanzania, it is important to establish if there is a continued use of chemoprevention against malaria among SCD children.

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