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sickle cell

Sickle cell disease and malaria: decreased exposure and asplenia can modulate the risk from Plasmodium falciparum

April 27, 2020 - 13:24 -- Open Access
Author(s): 
Richard O. Mwaiswelo, William Mawala, Per O. Iversen, Mariane de Montalembert, Lucio Luzzatto and Julie Makani
Reference: 
Malaria Journal 2020 19:165, 25 April 2020

Patients with sickle cell disease (SCD), an inherited haemoglobinopathy, have increased risk of malaria, at least in part due to impaired splenic function. Infection with Plasmodium falciparum in SCD patients can trigger painful vaso-occlusive crisis, increase the severity of anaemia, and contribute to early childhood mortality.

Utilization patterns of malaria chemoprophylaxis among Tanzanian children attending sickle cell clinic in Dar es Salaam tertiary hospitals

December 10, 2019 - 08:03 -- Open Access
Author(s): 
Esther J. Ndegeulaya, George M. Bwire, Raphael Z. Sangeda, Doreen Mloka, Faustine Tungaraza, Augustino S. Kahere, Fidelis F. Manyaki, Fatuma F. Felician, Manase Kilonzi, Wigilya P. Mikomangwa, Hamu J. Mlyuka, Alphonce I. Marealle, Ritah Mutagonda, Liberata Mwita and Kennedy D. Mwambete
Reference: 
Malaria Journal 2019 18:393, 3 December 2019

Malaria is among the leading cause of infection in individuals with sickle cell disease (SCD) living in sub-Saharan Africa, including Tanzania. However, after 2005 the standard treatment guidelines (STGs) on malaria chemoprevention for SCD patients were non-existent, and at present no medicine is recommended for SCD patients. Since several anti-malarials have been approved for the treatment of malaria in Tanzania, it is important to establish if there is a continued use of chemoprevention against malaria among SCD children.

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