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placental autophagy

Plasmodium falciparum infection dysregulates placental autophagy

December 10, 2019 - 11:05 -- Open Access
Lima FA, Barateiro A, Dombrowski JG, de Souza RM, Costa DS, Murillo O, Epiphanio S, Gonçalves LA, Marinho CRF
PLoS ONE 14(12): e0226117

Plasmodium (P.) falciparum malaria during pregnancy has been frequently associated with severe consequences such as maternal anemia, abortion, premature birth, and reduced birth weight. Placental damage promotes disruption of the local homeostasis; though, the mechanisms underlying these events are still to be elucidated. Autophagy is a fundamental homeostatic mechanism in the natural course of pregnancy by which cells self-recycle in order to survive in stressful environments. Placentas from non-infected and P. falciparum-infected women during pregnancy were selected from a previous prospective cohort study conducted in the Brazilian Amazon (Acre, Brazil).

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