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artemisinin activity

Not Open Access | Evolution of resistance in vitro reveals mechanisms of artemisinin activity in Toxoplasma gondii

December 10, 2019 - 08:43 -- NOT Open Access
Rosenberg A, Luth MR, Winzeler EA, Behnke M, Sibley LD
Proc Natl Acad Sci U S A. 2019 Dec 5. pii: 201914732

Artemisinins are effective against a variety of parasites and provide the first line of treatment for malaria. Laboratory studies have identified several mechanisms for artemisinin resistance in Plasmodium falciparum, including mutations in Kelch13 that are associated with delayed clearance in some clinical isolates, although other mechanisms are likely involved.

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