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sub-Saharan Africa

World Malaria Day 2021: Commemorating 15 Years of Contribution by the United States President's Malaria Initiative

April 28, 2021 - 14:22 -- Open Access
Steketee RW, Choi M, Linn A, Florey L, Murphy M, Panjabi R
Am J Trop Med Hyg. 2021 Apr 23:tpmd210432

World Malaria Day 2021 coincides with the 15th anniversary of the United States President's Malaria Initiative (PMI) and follows the first anniversary of the declaration of the coronavirus disease (COVID-19) pandemic. From 2006 to the present, the PMI has led to considerable country-managed progress in malaria prevention, care, and treatment in 24 of the highest-burden countries in sub-Saharan Africa and three countries in the Southeast Asia Greater Mekong subregion.

Co-infection of hepatitis E virus and Plasmodium falciparum malaria: A genuine risk in sub-Saharan Africa

April 22, 2021 - 08:35 -- Open Access
Sahra S, Jahangir A, Iqbal QZ, Mobarakai N, Glaser A, Jahangir A
Parasit Vectors. 2021 Apr 20;14(1):215

There is a high prevalence of malaria and viral hepatitis in South Africa. Co-infection with Plasmodium malaria (leading to cerebral malaria) and hepatitis E virus (HEV) is a rare phenomenon.

NOT Open Access | Blood transfusion and mortality in children with severe anaemia in a malaria-endemic region

April 22, 2021 - 08:32 -- NOT Open Access
Keating EM, Chiume M, Robison JA, et al.
Paediatr Int Child Health. 2021 Apr 19:1-8

In children in sub-Saharan Africa, severe anaemia (SA) is an important cause of mortality, and malaria is a primary cause. The World Health Organization (WHO) recommends blood transfusion for all children with haemoglobin (Hb) <4 g/dL and for those with Hb 4–6 g/dL with signs of instability. In sub-Saharan Africa, evidence of the effect on mortality of transfusion in children with SA with and without malaria is mixed.

A systematic review and meta-analysis of asymptomatic malaria infection in pregnant women in Sub-Saharan Africa: A challenge for malaria elimination efforts

April 7, 2021 - 12:07 -- Open Access
Yimam Y, Nateghpour M, Mohebali M, Abbaszadeh Afshar MJ
PLoS One. 2021 Apr 1;16(4):e0248245

In Sub-Saharan Africa (SSA), where malaria transmission is stable, malaria infection in pregnancy adversely affects pregnant women, fetuses, and newborns and is often asymptomatic. So far, a plethora of primary studies have been carried out on asymptomatic malaria infection in pregnant women in SSA. Nevertheless, no meta-analysis estimated the burden of asymptomatic malaria infection in pregnant women in SSA, so this meta-analysis was carried out to bridge this gap.

Community delivery of malaria intermittent preventive treatment in pregnancy: protocol of a quasi-experimental evaluation through multistage cluster sampling household surveys in four sub-Saharan African countries

March 31, 2021 - 14:29 -- Open Access
Pons-Duran C, Llach M, Sanz S, Ramírez M, Méndez S, Roman E, Tholandi M, Pagnoni F, Menendez C, González R
BMJ Open. 2021 Mar 25;11(3):e044680

In sub-Saharan Africa (SSA), millions of pregnant women are exposed to malaria infection. The cornerstone of the WHO strategy to prevent malaria in pregnancy in moderate to high-transmission areas is the administration of intermittent preventive treatment (IPTp) with sulfadoxine-pyrimethamine at each scheduled antenatal care (ANC) visit. However, overall coverage remains low. ‘Transforming IPT for Optimal Pregnancy’ (TIPTOP) project aims at delivering IPTp at the community level (C-IPTp) to complement ANC provision with the goal of increasing IPTp coverage and improving maternal and infant’s health. This protocol describes the approach to measure the effect of this strategy through household surveys (HHS) in four SSA countries: Democratic Republic of Congo (DRC), Madagascar, Mozambique and Nigeria.

COVID-19 and Syndemic challenges in 'Battling the Big Three': HIV, TB and malaria

March 31, 2021 - 14:20 -- Open Access
Velavan TP, Meyer CG, Esen M, Kremsner PG, Ntoumi F
Int J Infect Dis. 2021 Mar 26:S1201-9712(21)00289-7

Indirect effects of the COVID-19 pandemic have the potential to seriously undermine the health system in sub-Saharan Africa with an increase in the incidences of malaria, tuberculosis (TB) and HIV infections.

Role of vector control in fighting against malaria: Evidence from Ethiopian health-related indicators

March 24, 2021 - 15:12 -- Open Access
Mohammed MA, Hong T
J Infect Public Health. 2021 Mar 17;14(4):527-532

Due to a high burden imposed on public health from malaria disease in Sub-Saharan Africa, the vector control strategy is a significant concern. Despite the implementation of malaria control interventions in Ethiopia, it remains a major public health problem. Moreover, none of the prior researches was conducted in this title specifically. Therefore, this study investigates the impact of vector control interventions on malaria based on panel data of 10 malaria endemic-regions from 2000 to 2018.

NOT Open Access | Variation in Calculating and Reporting Antimalarial Efficacy against Plasmodium falciparum in Sub-Saharan Africa: A Systematic Review of Published Reports

March 17, 2021 - 17:13 -- NOT Open Access
Plucinski MM, Hastings IM, Moriarty LF, Venkatesan M, Felger I, Halsey ES
Am J Trop Med Hyg. 2021 Mar 15:tpmd201481

Antimalarials, in particular artemisinin-based combination therapies (ACTs), are critical tools in reducing the global burden of malaria, which is concentrated in sub-Saharan Africa. Performing and reporting antimalarial efficacy studies in a transparent and standardized fashion permit comparison of efficacy outcomes across countries and time periods. This systematic review summarizes study compliance with WHO laboratory and reporting guidance pertaining to antimalarial therapeutic efficacy studies and evaluates how well studies from sub-Saharan Africa adhered to these guidelines.

Chromosome-level genome assemblies of the malaria vectors Anopheles coluzzii and Anopheles arabiensis

March 17, 2021 - 16:50 -- Open Access
Zamyatin A, Avdeyev P, Liang J, Sharma A, Chen C, Lukyanchikova V, Alexeev N, Tu Z, Alekseyev MA, Sharakhov IV
Gigascience. 2021 Mar 15;10(3):giab017

Anopheles coluzzii and Anopheles arabiensis belong to the Anopheles gambiae complex and are among the major malaria vectors in sub-Saharan Africa. However, chromosome-level reference genome assemblies are still lacking for these medically important mosquito species.

Survivorship of Anopheles gambiae sensu lato in irrigated sugarcane plantation scheme in Ethiopia

March 10, 2021 - 13:18 -- Open Access
Hawaria D, Kibret S, Demissew A, Tsegaye A, Bitew D, Yan G, Yewhalaw D
Parasit Vectors. 2021 Mar 6;14(1):142

To ensure food security, sub-Saharan Africa has initiated massive water resource development projects, such as irrigated agriculture, in recent years. However, such environmental modifications affect the survivorship and development of mosquitoes, which are vectors of different diseases. This study aimed at determining the effects of irrigation practices on development and survivorship of Anopheles gambiae s.l. in Ethiopia.


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