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sub-Saharan Africa

Housing and child health in sub-Saharan Africa: A cross-sectional analysis

March 24, 2020 - 12:36 -- Open Access
Author(s): 
Lucy S. Tusting, Peter W. Gething, Harry S. Gibson, Brian Greenwood, Jakob Knudsen, Steve W. Lindsay, Samir Bhatt
Reference: 
PLoS Med 17(3): e1003055

Housing is essential to human well-being but neglected in global health. Today, housing in Africa is rapidly improving alongside economic development, creating an urgent need to understand how these changes can benefit health. We hypothesised that improved housing is associated with better health in children living in sub-Saharan Africa (SSA). We conducted a cross-sectional analysis of housing conditions relative to a range of child health outcomes in SSA.

Barriers to malaria prevention among immigrant travelers in the United States who visit friends and relatives in sub-Saharan Africa: A cross-sectional, multi-setting survey of knowledge, attitudes, and practices

March 18, 2020 - 14:24 -- Open Access
Author(s): 
Volkman HR, Walz EJ, Stauffer WM, et al.
Reference: 
PLoS One. 2020 Mar 12;15(3):e0229565

Despite achievements in the reduction of malaria globally, imported malaria cases to the United States by returning international travelers continue to increase. Immigrants to the United States from sub-Saharan Africa (SSA) who then travel back to their homelands to visit friends and relatives (VFRs) experience a disproportionate burden of malaria illness. Various studies have explored barriers to malaria prevention among VFRs and non-VFRs–travelers to the same destinations with other purpose for travel–but few employed robust epidemiologic study designs or performed comparative analyses of these two groups. To better quantify the key barriers that VFRs face to implement effective malaria prevention measures, we conducted a comprehensive community-based, cross-sectional, survey to identify differences in malaria prevention knowledge, attitudes, and practices (KAP) among VFRs and others traveling to Africa and describe the differences between VFRs and other types of international travelers.

Costs of insecticide-treated bed net distribution systems in sub-Saharan Africa

March 9, 2020 - 14:09 -- Open Access
Author(s): 
Sara S. Scates, Timothy P. Finn, Janna Wisniewski, David Dadi, Renata Mandike, Mwinyi Khamis, George Greer, Naomi Serbantez, Sylvester Segbaya, Prince Owusu, Jules Mihigo, Lilia Gerberg, Angela Acosta, Hannah Koenker and Joshua Yukich
Reference: 
Malaria Journal 2020 19:105, 4 March 2020

Insecticide-treated nets (ITNs) are one of the most cost-effective measures for preventing malaria. The World Health Organization recommends both large-scale mass distribution campaigns and continuous distributions (CD) as part of a multifaceted strategy to achieve and sustain universal access to ITNs. A combination of these strategies has been effective for scaling up ITN access. For policy makers to make informed decisions on how to efficiently implement CD or combined strategies, information on the costs and cost-effectiveness of these delivery systems is necessary, but relatively few published studies of the cost continuous distribution systems exist.

Prevalence of Plasmodium falciparum field isolates with deletions in histidine-rich protein 2 and 3 genes in context with sub-Saharan Africa and India: a systematic review and meta-analysis

February 3, 2020 - 16:36 -- Open Access
Author(s): 
Loick P. Kojom and Vineeta Singh
Reference: 
Malaria Journal 2020 19:46, 28 January 2020

In 2017, nearly 80% of malaria morbidity and mortality occurred in sub-Saharan African (SSA) countries and India. Rapid diagnostic tests (RDTs), especially those targeting histidine-rich protein 2 (PfHRP2) of Plasmodium falciparum, have become an important diagnostic tool in these malaria-endemic areas. However, the chances of RDT-oriented successful treatment are increasingly jeopardized by the appearance of mutants with deletions in pfhrp2 and pfhrp3 genes. This systematic review and meta-analysis determines the prevalence of field P. falciparum isolates with deletion in pfhrp2 and/or pfhrp3 genes and their proportion among false-negative results in the PfHRP2-based RDTs in SSA and India.

Safety and immunogenicity of the RTS,S/AS01 malaria vaccine in infants and children identified as HIV-infected during a randomized trial in sub-Saharan Africa

January 24, 2020 - 14:40 -- Open Access
Author(s): 
Otieno L, Guerra Mendoza Y, Oneko M, et al.
Reference: 
Vaccine Volume 38, Issue 4, 22 January 2020, Pages 897-906

We assessed the safety and immunogenicity of the RTS,S/AS01 malaria vaccine in a subset of children identified as HIV-infected during a large phase III randomized controlled trial conducted in seven sub-Saharan African countries.

Economic and Resource Use Associated With Management of Malaria in Children Aged <5 Years in Sub-Saharan Africa: A Systematic Literature Review

January 14, 2020 - 16:39 -- Open Access
Author(s): 
El-Houderi A, Constantin J, Castelnuovo E, Sauboin C
Reference: 
MDM Policy & Practice, 2019 Dec 21;4(2):2381468319893986.

Malaria is a major health, economic, and social burden in sub-Saharan Africa. The objective is to help understanding the economic impact of malaria and informing estimates of the potential economic impact of malaria prevention. To achieve this, we conducted a systematic review of published information on health system costs, health care resource use, and household costs for the management of malaria episodes in children aged <5 years in sub-Saharan Africa.

A Systematic Review of the Incremental Costs of Implementing a New Vaccine in the Expanded Program of Immunization in Sub-Saharan Africa

January 14, 2020 - 16:33 -- Open Access
Author(s): 
Brew J, Sauboin C
Reference: 
MDM Policy & Practice, 2019 Dec 19; 4(2):2381468319894546

The World Health Organization is planning a pilot introduction of a new malaria vaccine in three sub-Saharan African countries. To inform considerations about including a new vaccine in the vaccination program of those and other countries, estimates from the scientific literature of the incremental costs of doing so are important

The Costs of Implementing Vaccination With the RTS,S Malaria Vaccine in Five Sub-Saharan African Countries

January 14, 2020 - 16:32 -- Open Access
Author(s): 
Sicuri E, Yaya Bocoum F, Nonvignon J, Alonso S, Fakih B, Bonsu G, Kariuki S, Leeuwenkamp O, Munguambe K, Mrisho M, Were V, Sauboin C
Reference: 
MDM Policy & Practice, 2019 Dec 19;4(2):2381468319896280

The World Health Organization has recommended pilot implementation of a candidate vaccine against malaria (RTS,S/AS01) in selected sub-Saharan African countries. This exploratory study aimed to estimate the costs of implementing RTS,S in Burkina Faso, Ghana, Kenya, Mozambique, and Tanzania.

Who buys nets? Factors associated with ownership and use of purchased mosquito nets in sub-Saharan Africa

December 10, 2019 - 08:32 -- Open Access
Author(s): 
Olapeju B, Choiriyyah I, Bertram K, Piccinini D, Harig H, Selby RA, Lynch M, Koenker H
Reference: 
Malar J. 2019 Dec 4; 18(1):401

Public sector strategies to promote insecticide-treated net (ITN) access have resulted in increased ITN ownership across sub-Saharan Africa. However, the current status of the private sector distribution channel for nets has not been fully explored. This multi-country study explored the prevalence of net purchases and the characteristics of households that had purchased nets and used such nets in sub-Saharan Africa.

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