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Retrospective evaluation of the effectiveness of indoor residual spray with pirimiphos‐methyl (Actellic) on malaria transmission in Zambia

April 7, 2021 - 12:46 -- Open Access
Joseph Keating, Joshua O. Yukich, John M. Miller, Sara Scates, Busiku Hamainza, Thomas P. Eisele and Adam Bennett
Malaria Journal 2021 20:173, 1 April 2021

Widespread insecticide resistance to pyrethroids could thwart progress towards elimination. Recently, the World Health Organization has encouraged the use of non-pyrethroid insecticides to reduce the spread of insecticide resistance. An electronic tool for implementing and tracking coverage of IRS campaigns has recently been tested (mSpray), using satellite imagery to improve the accuracy and efficiency of the enumeration process. The purpose of this paper is to retrospectively analyse cross-sectional observational data to provide evidence of the epidemiological effectiveness of having introduced Actellic 300CS and the mSpray platform into IRS programmes across Zambia.

Modelling of malaria risk, rates, and trends: A spatiotemporal approach for identifying and targeting sub-national areas of high and low burden

March 2, 2021 - 15:21 -- Open Access
Lubinda J, Bi Y, Hamainza B, Haque U, Moore AJ
PLoS Comput Biol. 2021 Mar 1;17(3):e1008669

While mortality from malaria continues to decline globally, incidence rates in many countries are rising. Within countries, spatial and temporal patterns of malaria vary across communities due to many different physical and social environmental factors. To identify those areas most suitable for malaria elimination or targeted control interventions, we used Bayesian models to estimate the spatiotemporal variation of malaria risk, rates, and trends and determine areas of high or low malaria burden compared to their geographical neighbours.

Geographically extensive larval surveys reveal an unexpected scarcity of primary vector mosquitoes in a region of persistent malaria transmission in western Zambia

February 2, 2021 - 16:35 -- Open Access
Cross DE, Thomas C, McKeown N, Siaziyu V, Healey A, Willis T, Singini D, Liywalii F, Silumesii A, Sakala J, Smith M, Macklin M, Hardy AJ, Shaw PW
Parasit Vectors. 2021 Feb 1;14(1):91

The Barotse floodplains of the upper Zambezi River and its tributaries are a highly dynamic environment, with seasonal flooding and transhumance presenting a shifting mosaic of potential larval habitat and human and livestock blood meals for malaria vector mosquitoes. However, limited entomological surveillance has been undertaken to characterize the vector community in these floodplains and their environs. Such information is necessary as, despite substantial deployment of insecticide-treated nets (ITNs) and indoor residual spraying (IRS) against Anopheles vectors, malaria transmission persists across Barotseland in Zambia’s Western Province.

Sulfadoxine-pyrimethamine parasitological efficacy against Plasmodium falciparum among pregnant women and molecular markers of resistance in Zambia: an observational cohort study

January 27, 2021 - 15:46 -- Open Access
Enesia Banda Chaponda, Sungano Mharakurwa, Charles Michelo, Jane Bruce, Daniel Chandramoha and R. Matthew Chico
Malaria Journal 2021 20:61, 22 January 2021

The World Health Organization recommends the provision of intermittent preventive treatment during pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) at 4-week intervals from gestational week 13 to delivery in areas of moderate to high malaria transmission intensity. However, the effect of IPTp-SP has been compromised in some areas due to parasite resistance, raising the importance of parasitological and chemoprophylactic surveillance, and monitoring SP-resistance markers in the Plasmodium falciparum population.

Near-term climate change impacts on sub-national malaria transmission

January 16, 2021 - 15:52 -- Open Access
Lubinda J, Haque U, Bi Y, Hamainza B, Moore AJ
Sci Rep. 2021 Jan 12;11(1):751

The role of climate change on global malaria is often highlighted in World Health Organisation reports. We modelled a Zambian socio-environmental dataset from 2000 to 2016, against malaria trends and investigated the relationship of near-term environmental change with malaria incidence using Bayesian spatio-temporal, and negative binomial mixed regression models.

The Impact of Three Years of Targeted Indoor Residual Spraying with Pirimiphos-Methyl on Household Vector Abundance in a High Malaria Transmission Area of Northern Zambia

December 23, 2020 - 08:53 -- Open Access
Hast MA, Stevenson JC, Muleba M, Chaponda M, Kabuya JB, Mulenga M, Shields T, Moss WJ, Norris DE
Am J Trop Med Hyg. 2020 Dec 21

The global malaria burden has decreased substantially, but gains have been uneven both within and between countries. In Zambia, the malaria burden remains high in northern and eastern regions of the country. To effectively reduce malaria transmission in these areas, evidence-based intervention strategies are needed. Zambia's National Malaria Control Centre conducted targeted indoor residual spraying (IRS) in 40 high-burden districts from 2014 to 2016 using the novel organophosphate insecticide pirimiphos-methyl.

Prevalence, characteristics and risk factors of imported and local malaria cases in North-Western Province, Zambia: a cross-sectional study

November 24, 2020 - 15:08 -- Open Access
Maureen N. Chipoya and Nzooma M. Shimaponda-Mataa
Malaria Journal 2020 19:430, 23 November 2020

Imported malaria is a major challenge for countries that are in malaria elimination stage such as Zambia. Legitimate cross-border activities add to the risk of transmission, necessitating determination of prevalence, characteristics and risk factors of imported and local malaria.

Costing malaria interventions from pilots to elimination programmes

September 15, 2020 - 10:34 -- Open Access
Katya Galactionova, Mar Velarde, Kafula Silumbe, John Miller, Anthony McDonnell, Ricardo Aguas, Thomas A. Smith and Melissa A. Penny
Malaria Journal 2020 19:332, 14 September 2020

Malaria programmes in countries with low transmission levels require evidence to optimize deployment of current and new tools to reach elimination with limited resources. Recent pilots of elimination strategies in Ethiopia, Senegal, and Zambia produced evidence of their epidemiological impacts and costs. There is a need to generalize these findings to different epidemiological and health systems contexts.

Comparing prioritization strategies for delivering indoor residual spray (IRS) implementation, using a network approach

September 8, 2020 - 11:52 -- Open Access
Sadie J. Ryan, Anne C. Martin, Bhavneet Walia, Anna Winters and David A. Larsen
Malaria Journal 2020 19:326, 4 September 2020

Indoor residual spraying (IRS) is an effective method to control malaria-transmitting Anopheles mosquitoes and often complements insecticide-treated mosquito nets, the predominant malaria vector control intervention. With insufficient funds to cover every household, malaria control programs must balance the malaria risk to a particular human community against the financial cost of spraying that community. This study creates a framework for modelling the distance to households for targeting IRS implementation, and applies it to potential risk prioritization strategies in four provinces (Luapula, Muchinga, Eastern, and Northern) in Zambia.

NOT Open Access | CYB5R3(c) (.350C>G) and G6PD A Alleles Modify Severity of Anemia in Malaria and Sickle Cell Disease

July 26, 2020 - 13:26 -- NOT Open Access
Gordeuk VR, Shah BN, Prchal JT, et al.
Am J Hematol. 2020 Jul 22

Genetic modifiers of anemia in Plasmodium falciparum infection and sickle cell disease (SCD) are not fully known. Both conditions are associated with oxidative stress, hemolysis and anemia. CYB5R3 encodes cytochrome b5 reductase 3, which converts methemoglobin to hemoglobin through oxidation of NADH. CYB5R3c.350C>G , the most frequent recognized African-specific polymorphism, does not have known functional significance, but its high allele frequency (23% in African-Americans) suggests a selection advantage.


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