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artemisinin; bone marrow; chloroquine; drug evasion; drug failure; drug resistance; hypnozoite; malaria; merozoite; Plasmodium vivax; primaquine; recrudescence; recurrence; relapse; spleen

Significance of time to clinical recurrence in vivax malaria

October 12, 2018 - 10:55 -- Miles Markus

The amount of time that passes between a symptomatic vivax malarial episode and a subsequent recurrence has in the past often been regarded as an indication as to whether the recurrence is a relapse (hypnozoite origin) or a recrudescence (merozoite origin). It should be noted that in the light of new knowledge and understanding, the time factor is not a valid criterion. (Link to first paper). (Link to second paper).

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