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sub-Saharan Africa

Open Access | Effect of incentives on insecticide-treated bed net use in sub-Saharan Africa: a cluster randomized trial in Madagascar

June 29, 2010 - 10:05 -- Kabogo Ndegwa
Author(s): 
Krezanoski PJ, Comfort AB, Hamer DH
Reference: 
Malaria Journal 2010, 9:186 (27 June 2010)

Household-level incentives have the potential to significantly increase the use of ITNs in target households in the immediate-term, but, over time, the use of ITNs is similar to households that did not receive incentives.

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Open Access | The Cost-Effectiveness of Intermittent Preventive Treatment for Malaria in Infants in Sub-Saharan Africa

June 18, 2010 - 10:37 -- Kabogo Ndegwa
Author(s): 
Lesong Conteh, Elisa Sicuri, Marcel Tanner, .et al
Reference: 
PLoS ONE 5(6): e10313

IPTi delivered alongside the EPI is a highly cost effective intervention against clinical malaria with a range of drugs in a range of malaria transmission settings. Where IPTi did not have a statistically significant impact on malaria, generally in low transmission sites, it was not cost effective.

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Open Access | Population genetic structure of the malaria vector Anopheles nili in sub-Saharan Africa

June 15, 2010 - 06:56 -- Kabogo Ndegwa
Author(s): 
Ndo C, Antonio-Nkondjio C, Cohuet A, Ayala D, Kengne P, Morlais I, Awono-Ambene PH, Couret D, Ngassam P, Fontenille D, Simard F
Reference: 
Malaria Journal 2010, 9:161 (12 June 2010)

Overall, high genetic homogeneity of the An. nili gene pool was found across its distribution range in West and Central Africa, although demographic events probably resulted in a higher level of genetic isolation in the marginal population of Kenge (DRC).

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An exploratory survey of malaria prevalence and people's knowledge, attitudes and practices of mosquito larval source management for malaria control in western Kenya

June 9, 2010 - 08:18 -- Kabogo Ndegwa
Author(s): 
S.S. Imbahale, U. Fillinger, A. Githeko, W.R. Mukabana, W. Takken
Reference: 
Acta Tropica, Volume 115, Issue 3, September 2010, Pages 248-256

A large proportion of mosquito larval habitats in urban and rural communities in sub-Saharan Africa are man-made. Therefore, community-based larval source management (LSM) could make a significant contribution to malaria control in an integrated vector management approach.

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Doxycycline-chloroquine vs. doxycycline-placebo for malaria prophylaxis in nonimmune soldiers: a double-blind randomized field trial in sub-Saharan Africa

March 26, 2010 - 16:17 -- Kabogo Ndegwa
Author(s): 
Rémy Michel, Sébastien Bardot, Benjamin Queyriaux, Jean-Paul Boutin, Jean-Etienne Touze
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 4, April 2010, Pages 290-297

Our results showed that a doxycycline-chloroquine combination could be a safe combination for malaria chemoprophylaxis.

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Open Access | Age-Patterns of Malaria Vary with Severity, Transmission Intensity and Seasonality in Sub-Saharan Africa: A Systematic Review and Pooled Analysis

February 9, 2010 - 12:47 -- Ingeborg van Schayk
Author(s): 
Ilona Carneiro, Arantxa Roca-Feltrer, Jamie T. Griffin, Lucy Smith, Marcel Tanner, Joanna Armstrong Schellenberg, Brian Greenwood, David Schellenberg
Reference: 
PLoS ONE 5(2): e8988

We have, therefore, undertaken a pooled analysis of existing data from multiple sites to enable a comprehensive overview of the age-patterns of malaria outcomes under different epidemiological conditions in sub-Saharan Africa.

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Open Access | Decreasing childhood mortality and increasing proportion of malaria deaths in rural Burkina Faso

December 24, 2009 - 14:00 -- Ingeborg van Schayk
Author(s): 
Heribert Ramroth1*§, Robert P. Ndugwa1§, Olaf Mu¨ ller1, Yazoume Ye´ 2, Ali Sie´ 3, Bocar Kouyate´ 4 and Heiko Becher1
Reference: 
Global Health Action 2009

The aim of this study was to describe temporal trends for malaria and all-cause mortality by combining a series of clinical and intervention studies conducted in Burkina Faso.

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Special Focus Review: From the circumsporozoite protein to the RTS,S/AS candidate vaccine

October 25, 2009 - 16:43 -- Ingeborg van Schayk
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Author(s): 
Joe Cohen, Victor Nussenzweig, Johan Vekemans and Amanda Leach
Reference: 
Human Vaccines, Volume 6, Issue 1, January 2010

The RTS,S/AS01E malaria vaccine candidate has recently entered phase 3 testing. Reaching this important milestone is the culmination of more than 20 years of research and development by GlaxoSmithKline and partners and collaborators. The vaccine has been developed to protect young children and infants living in sub-Saharan Africa against clinical and severe disease caused by Plasmodium falciparum infection.

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