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sub-Saharan Africa

Open Access | Plasmodium falciparum msp1, msp2 and glurp allele frequency and diversity in sub-Saharan Africa

April 20, 2011 - 11:24 -- Kabogo Ndegwa
Author(s): 
Felista Mwingira, Gamba Nkwengulila, Sonja Schoepflin, Deborah Sumari, Hans-Peter Beck, Georges Snounou, Ingrid Felger, Piero Olliaro, Kefas Mugittu
Reference: 
Malaria Journal 2011, 10:79 (6 April 2011)

Plasmodium falciparum msp1, msp2 and glurp markers were highly polymorphic with low allele frequencies. A total of 17 msp1 genotypes [eight MAD20-, one RO33- and eight K1-types]; 116 msp2 genotypes [83 3D7 and 33 FC27- types] and 14 glurp genotypes were recorded.

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Open Access | Aquaporin water channel AgAQP1 in the malaria vector mosquito Anopheles gambiae during blood feeding and humidity adaptation

April 14, 2011 - 11:44 -- Kabogo Ndegwa
Author(s): 
Kun Liu, Hitoshi Tsujimoto, Sung-Jae Cha, Peter Agre and Jason L. Rasgon
Reference: 
PNAS April 12, 2011 vol. 108 no. 15 6062-6066

Altered patterns of malaria endemicity reflect, in part, changes in feeding behavior and climate adaptation of mosquito vectors.

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Open Access | Case Management of Severe Malaria - A Forgotten Practice: Experiences from Health Facilities in Uganda

March 8, 2011 - 07:18 -- Kabogo Ndegwa
Author(s): 
Jane Achan, James Tibenderana, Daniel Kyabayinze, Henry Mawejje, Rukaaka Mugizi, Betty Mpeka, Ambrose Talisuna, Umberto D'Alessandro
Reference: 
PLoS ONE 6(3): e17053

Management of severe malaria in Ugandan health facilities was sub-optimal. These findings highlight the challenges of correctly managing severe malaria in resource limited settings.

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Open Access | Prevalence of Plasmodium falciparum infection in asymptomatic rural Gabonese populations

February 10, 2011 - 11:51 -- Kabogo Ndegwa
Author(s): 
Nkoghe D, Akue J, Gonzalez J, Leroy EM
Reference: 
Malaria Journal 2011, 10:33 (9 February 2011)

Plasmodium falciparum carriage remains high among adults in rural Gabon. Control measures must be adapted to the region and ecosystem. Routine treatment of asymptomatic individuals should be considered.

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Open Access | Community response to intermittent preventive treatment of malaria in infants (IPTi) in Papua New Guinea

December 23, 2010 - 14:00 -- Kabogo Ndegwa
Author(s): 
Pell C, Straus L, Phuanukoonnon S, Lupiwa S, Mueller I, Senn N, Siba P, Gysels M, Pool R
Reference: 
Malaria Journal 2010, 9:369 (22 December 2010)

The degree of similarity between findings from the acceptability studies undertaken in sub-Saharan Africa and PNG allows some generalization relating to the implementation of IPTi outside of Africa:

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Open Access | Odorant-Binding Proteins of the Malaria Mosquito Anopheles funestus sensu stricto

October 30, 2010 - 12:31 -- Kabogo Ndegwa
Author(s): 
Wei Xu, Anthony J. Cornel, Walter S. Leal
Reference: 
PLoS ONE 5(10): e15403.

This work presents for the first time a study on the odorants and OBPs of the malaria vector mosquito An. funestus, which may provide insight into the An.

Open Access | The age patterns of severe malaria syndromes in sub-Saharan Africa across a range of transmission intensities and seasonality settings

October 17, 2010 - 08:41 -- Kabogo Ndegwa
Author(s): 
Roca-Feltrer A, Carneiro I, Smith L, Armstrong Schellenberg JR, Greenwood B, Schellenberg D
Reference: 
Malaria Journal 2010, 9:282 (13 October 2010)

Although the peak age of CM will increase as transmission intensity decreases in Africa, more than 75% of all paediatric hospital admissions of severe malaria are likely to remain in under five year olds in most epidemiological settings.

Open Access | Poverty and fever vulnerability in Nigeria: a multilevel analysis

August 20, 2010 - 13:19 -- Kabogo Ndegwa
Author(s): 
Yusuf OB, Adeoye BW, Oladepo OO, Peters DH, Bishai D
Reference: 
Malaria Journal 2010, 9:235 (19 August 2010)

While, overall bednet possession was low, less fever was reported in households that possessed bednets. Malaria control strategies and interventions should be designed that will target the poor and make an impact on poverty.

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Review: The RTS, S malaria vaccine

July 21, 2010 - 06:47 -- Patrick Sampao
Author(s): 
Sofia Casares, Teodor-Doru Brumeanu, Thomas L. Richie
Reference: 
Vaccine, Volume 28, Issue 31, 12 July 2010, Pages 4880-4894

This review will focus on current knowledge about the protective efficacy of RTS,S and what we have learned regarding its impact on the human immune system.

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Malaria: passive case detection and healthcare providers' choices of chemotherapy

July 19, 2010 - 12:26 -- Kabogo Ndegwa
Author(s): 
Fehintola FA, Balogun ST
Reference: 
Afr J Med Med Sci 2010 Mar; 39(1):49-54.

Prompt diagnosis and treatment play a central role in the malaria control programme in sub Saharan Africa. However, in most cases the diagnoses are never confirmed either for lack of facility or disinterest of healthcare providers resulting in over-diagnosis.

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