This study shows that despite frequent active screening and prompt treatment of MiP, impaired growth and an increased risk of malaria and non-malaria infections can be observed in the infants.
DHA-PQ was effective and well tolerated in the treatment of uncomplicated malaria and provides an excellent alternative first-line ACT in sub-Saharan Africa.
IPTp coverage measured by household surveys is unsatisfactorily low, even many years after policy adoption.
Malaria in sub-Saharan Africa has historically been almost exclusively attributed to Plasmodium falciparum (Pf).
Although the results are speculative (e.g., they are based on parameter estimates that do not possess the traditional statistical significance level), the biological plausibility of the modelling assumptions and the high price-sensitivity of demand for bed nets suggest that free bed net distribution targeted to undernutritioned children in areas suffering from both undernutrition and malaria (e.g., sub-Saharan Africa) should be the subject of a randomized trial in a hypoendemic or mesoendemic setting.
Although the burden of malaria is decreasing, parasite resistance to current antimalarial drugs and resistance to insecticides by vector mosquitoes threaten the prospects of malaria elimination in endemic areas.
Molecular methods provide information about genetic diversity, the intensity of transmission and spontaneous clearance in the absence of drug treatment that cannot be obtained by microscopy.
Urbanicity has been shown previously to lead to a reduction in malaria transmission at large spatial scales.
In immunocompetent individuals, non-typhoidal Salmonella serovars (NTS) are associated with gastroenteritis, however, there is currently an epidemic of NTS bloodstream infections in sub-Saharan Africa.
In sub-Saharan Africa, dams contribute significantly to malaria risk particularly in areas of unstable transmission.