Next-generation sequencing (NGS) technologies are increasingly being used to address a diverse range of biological and epidemiological questions.
Parasite resistance against anti-malarial drugs is a major threat to the ongoing malaria control and elimination strategies.
Unlike the case in Asia and Latin America, Plasmodium vivax infections are rare in sub-Saharan Africa due to the absence of the Duffy blood group antigen (Duffy antigen), the only known erythrocyte receptor for the P. vivax merozoite invasion ligand, Duffy binding protein 1 (DBP1).
Populations in sub-Saharan Africa have historically been exposed to intense selection from chronic infection with falciparum malaria.
Malaria remains a major global threat to human health and economic development.
While the importance of understanding human-vector interaction is well-established, relatively few studies have included human behaviour when measuring exposure to malaria vectors.
The present study gave the first molecular evidence of P. vivax in Nigeria in Duffy negative individuals.
In sub-Saharan Africa, inherited causes of anemia are common, but data are limited regarding the geographical prevalence and coinheritance of these conditions and their overall contributions to childhood anemia.
Parasite clearance following treatment with intravenous artesunate was rapid and adequate.
This protocol for high purity high yield B cell and Th cell isolation and sample storage for subsequent qRT-PCR analysis from a minimal amount of blood is contrivable with basic equipment and independent of continuous power supply.