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sub-Saharan Africa

Applying next-generation sequencing to track falciparum malaria in sub-Saharan Africa

September 10, 2019 - 15:31 -- Open Access
Author(s): 
Sofonias K. Tessema, Jaishree Raman, Craig W. Duffy, Deus S. Ishengoma, Alfred Amambua-Ngwa and Bryan Greenhouse
Reference: 
Malaria Journal 2019 18:268, 3 September 2019

Next-generation sequencing (NGS) technologies are increasingly being used to address a diverse range of biological and epidemiological questions.

Deployment and utilization of next-generation sequencing of Plasmodium falciparum to guide anti-malarial drug policy decisions in sub-Saharan Africa: opportunities and challenges

September 10, 2019 - 15:29 -- Open Access
Author(s): 
Deus S. Ishengoma, Queen Saidi, Carol H. Sibley, Cally Roper and Michael Alifrangis
Reference: 
Malaria Journal 2019 18:267, 3 September 2019

Parasite resistance against anti-malarial drugs is a major threat to the ongoing malaria control and elimination strategies.

Not Open Access | Transcriptome profiling of Plasmodium vivax in Saimiri monkeys identifies potential ligands for invasion

April 9, 2019 - 13:08 -- NOT Open Access
Author(s): 
Karthigayan Gunalan, Juliana M. Sá, Louis H. Miller, et al.
Reference: 
PNAS April 2, 2019 116 (14) 7053-7061

Unlike the case in Asia and Latin America, Plasmodium vivax infections are rare in sub-Saharan Africa due to the absence of the Duffy blood group antigen (Duffy antigen), the only known erythrocyte receptor for the P. vivax merozoite invasion ligand, Duffy binding protein 1 (DBP1).

Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt"

March 28, 2019 - 15:58 -- Open Access
Tags: 
Author(s): 
Mateus H. Gouveia, Andrew W. Bergen, Sam M. Mbulaiteye, et al.
Reference: 
PLoS Genet 15(3): e1008027

Populations in sub-Saharan Africa have historically been exposed to intense selection from chronic infection with falciparum malaria.

NOT Open Access | Human erythrocyte band 3 is a host receptor for Plasmodium falciparum glutamic acid–rich protein

February 6, 2019 - 15:33 -- NOT Open Access
Tags: 
Author(s): 
Haifa Almukadi, Christopher Schwake, Maima M. Kaiser, D. C. Ghislaine Mayer, James Schiemer, Michael R. Baldwin, Shreeya Hegde, Yunzhe Lu, Toshihiko Hanada and Athar H. Chishti
Reference: 
Blood 2019 133:470-480

Malaria remains a major global threat to human health and economic development.

Measuring and characterizing night time human behaviour as it relates to residual malaria transmission in sub-Saharan Africa: a review of the published literature

January 15, 2019 - 15:22 -- Open Access
Tags: 
Author(s): 
April Monroe, Sarah Moore, Hannah Koenker, Matthew Lynch and Emily Ricotta
Reference: 
Malaria Journal 2019 18:6, 11 January 2019

While the importance of understanding human-vector interaction is well-established, relatively few studies have included human behaviour when measuring exposure to malaria vectors.

Molecular identification of Plasmodium species responsible for malaria reveals Plasmodium vivax isolates in Duffy negative individuals from southwestern Nigeria

December 4, 2018 - 14:32 -- Open Access
Author(s): 
Mary Aigbiremo Oboh, Aida Sadikh Badiane, Godwin Ntadom, Yaye Die Ndiaye, Khadim Diongue, Mamadou Alpha Diallo and Daouda Ndiaye
Reference: 
Malaria Journal 2018 17:439, 28 November 2018

The present study gave the first molecular evidence of P. vivax in Nigeria in Duffy negative individuals.

Prevalence of inherited blood disorders and associations with malaria and anemia in Malawian children

November 21, 2018 - 15:24 -- Open Access
Tags: 
Author(s): 
Patrick T. McGann, Anne M. Williams, Parminder S. Suchdev, et al.
Reference: 
Blood Advances 2018 2:3035-3044

In sub-Saharan Africa, inherited causes of anemia are common, but data are limited regarding the geographical prevalence and coinheritance of these conditions and their overall contributions to childhood anemia.

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Assessment of parasite clearance following treatment of severe malaria with intravenous artesunate in Ugandan children enrolled in a randomized controlled clinical trial

October 31, 2018 - 15:33 -- Open Access
Tags: 
Author(s): 
Pauline Byakika-Kibwika, Patience Nyakato, Mohammed Lamorde and Agnes N. Kiragga
Reference: 
Malaria Journal 2018 17:400, 30 October 2018

Parasite clearance following treatment with intravenous artesunate was rapid and adequate.

High purity high yield tandem B and T helper cell isolation for qRT-PCR analysis suitable for basically equipped laboratories

October 31, 2018 - 15:22 -- Open Access
Tags: 
Author(s): 
Andrea Maria Summerauer, Lorenzo Colombo, Rodney Ogwang, Christoph Berger, Jan Fehr and Simone Bürgler
Reference: 
Malaria Journal 2018 17:395, 29 October 2018

This protocol for high purity high yield B cell and Th cell isolation and sample storage for subsequent qRT-PCR analysis from a minimal amount of blood is contrivable with basic equipment and independent of continuous power supply.

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