NOT Open Access | Substantial increase in mutations in the genes pfdhfr and pfdhps puts sulphadoxine–pyrimethamine-based intermittent preventive treatment for malaria at risk in Burkina Faso
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Tropical Medicine & International Health Volume 19, Issue 6, pages 690–697, June 2014
The increase in molecular markers linked with SP resistance jeopardises the efficacy of IPTp and the planned IPTi interventions in Burkina Faso, calling for careful monitoring of genotypic resistance markers and in vivo validation of IPT efficacy.
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Our literature review identified 17 relevant studies from the period 1980–2009 and indicated that the median prevalence of malaria among 33,029 blood donors was 10.2% (range, 0.7% in Kenya to 55.0% in Nigeria).