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Southeast Asia

Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework

March 13, 2019 - 14:40 -- Open Access
Gael Davidson, Tock H. Chua, Angus Cook, Peter Speldewinde and Philip Weinstein
Malaria Journal 2019 18:66, 8 March 2019

Plasmodium knowlesi is a zoonotic malaria parasite normally residing in long-tailed and pig-tailed macaques (Macaca fascicularis and Macaca nemestrina, respectively) found throughout Southeast Asia.

Distribution and prevalence of malaria parasites among long-tailed macaques (Macaca fascicularis) in regional populations across Southeast Asia

September 6, 2016 - 18:12 -- Open Access
Xinjun Zhang, Khamisah Abdul Kadir, Leslie Fabiola Quintanilla-Zariñan, Jason Villano, Paul Houghton, Hongli Du, Balbir Singh and David Glenn Smith
Malaria Journal 2016 15:450, 2 September 2016


The prevalence of malaria parasites, including those that are transmissible to humans, varied among all sampled regional populations of long-tailed macaques in Southeast Asia.

Polymorphisms in K13 and Falcipain-2 Associated with Artemisinin Resistance Are Not Prevalent in Plasmodium falciparum Isolated from Ugandan Children

September 4, 2014 - 13:21 -- Open Access
Melissa D. Conrad, Victor Bigira, James Kapisi, Mary Muhindo, Moses R. Kamya, Diane V. Havlir, Grant Dorsey, Philip J. Rosenthal
PLoS ONE 9(8): e105690

The emergence of resistance to artemisinin derivatives in Southeast Asia, manifested as delayed clearance of Plasmodium falciparum following treatment with artemisinins, is a major concern.

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

August 5, 2014 - 16:31 -- Open Access
Elizabeth A. Ashley, Mehul Dhorda, Nicholas J. White, et al
N Engl J Med 2014; 371:411-423July 31, 2014

In western Cambodia, where artemisinin-based combination therapies are failing, the 6-day course of antimalarial therapy was associated with a cure rate of 97.7% (95% confidence interval, 90.9 to 99.4) at 42 days.

Open Access | Modelling knowlesi malaria transmission in humans: vector preference and host competence

November 24, 2010 - 07:49 -- Kabogo Ndegwa
Laith Yakob, Michael B Bonsall, Guiyun Yan
Malaria Journal 2010, 9:329 (16 November 2010)

These threshold conditions are discussed in the context of malaria vector-parasite co-evolution as a function of anthropogenic effects.

Medical Condition: 
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