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Not Open Access | Effects of experimental cerebral malaria in memory, brain-derived neurotrophic factor and acetylcholinesterase acitivity in the hippocampus of survivor mice

August 1, 2012 - 13:08 -- Patrick Sampao
Author(s): 
Clarissa M. Comim, Patrícia A. Reis, Hugo C. Castro-Faria-Neto, et al.
Reference: 
Neuroscience Letters, Volume 523, Issue 2, 15 August 2012, Pages 104–107

MalariaWorldIn the present work, we evaluated BDNF protein levels and AChE activity in the hippocampus and habituation in an animal model of CM using C57BL/6 mice after fifteen days of the induction.

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Not Open Access | A recombinant Bacille Calmette–Guérin construct expressing the Plasmodium falciparum circumsporozoite protein enhances dendritic cell activation and primes for circumsporozoite-specific memory cells in BALB/c mice

July 24, 2012 - 15:03 -- Patrick Sampao
Author(s): 
Charles Arama, Shahid Waseem, Marita Troye-Blomberg, et al.
Reference: 
Vaccine, Volume 30, Issue 37, 10 August 2012, Pages 5578-5584

MalariaWorldWe assessed in vitro and in vivo a recombinant BCG-expressing CSp (BCG-CS) as malaria vaccine candidate. Immunisation of BALB/c mice with BCG-CS augmented numbers of dendritic cells (DCs) in draining lymph nodes and in the spleen.

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Evaluation of immune responses to a Plasmodium vivax CSP-based recombinant protein vaccine candidate in combination with second-generation adjuvants in mice

April 18, 2012 - 13:47 -- Patrick Sampao
Author(s): 
Joanne M. Lumsden, Saule Nurmukhambetova, Anjali Yadava, et al.
Reference: 
Vaccine, Volume 30, Issue 22, 9 May 2012, Pages 3311-3319

MalariaWorldIn this study, groups of C57BL/6J mice were immunized subcutaneously three times with VMP001 emulsified with synthetic TLR4 (GLA) or TLR7/8 (R848) agonist in stable emulsion (SE), a combination of the TLR4 and TLR7/8 agonists, or SE alone.

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Kinetics of Humoral and Memory B Cell Response Induced by the Plasmodium falciparum 19-Kilodalton Merozoite Surface Protein 1 in Mice

January 23, 2012 - 09:43 -- Patrick Sampao
Author(s): 
Mwanaidi Y. Kafuye-Mlwilo, Paushali Mukherjee and Virander S. Chauhan
Reference: 
Infect. Immun. February 2012 vol. 80 no. 2 633-642

MalariaWorldOur findings suggest that PfMSP-119-specific IgG production by short-lived plasma cells combined with the poor ability of the PfMSP-119-induced MBCs to maintain the anamnestic IgG responses failed to contribute to protection against infection.

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The effect of helminth co-infection on malaria in mice: A meta-analysis

September 28, 2011 - 07:40 -- Patrick Sampao
Author(s): 
Sarah C.L. Knowles
Reference: 
International Journal for Parasitology,Volume 41, Issue 10, 15 August 2011, Pages 1041-1051

Here, meta-analysis of 42 mouse co-infection experiments was used to address how helminths influence malaria parasite replication and host mortality, and explore the factors explaining variation in findings.

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A recombinant vaccine based on domain II of Plasmodium vivax Apical Membrane Antigen 1 induces high antibody titres in mice

August 16, 2010 - 14:24 -- Patrick Sampao
Author(s): 
Fernanda G., Daniel Y., et al
Reference: 
Vaccine, Volume 28, Issue 38, 31 August 2010, Pages 6183-6190

These results demonstrate that a recombinant protein containing PvAMA-1 DII is immunogenic when administered in different adjuvant formulations, and indicate that this region of the AMA-1 protein should continue to be evaluated as part of a subunit vaccine against vivax malaria.

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Review | Of mice and women: rodent models of placental malaria

July 22, 2010 - 09:16 -- Patrick Sampao
Author(s): 
Lars Hviid, Claudio R.F. Marinho, Trine Staalsoe, Carlos Penha-Gonçalves
Reference: 
Trends in Parasitology, Volume 26, Issue 8, August 2010, Pages 412-419

Placental IE sequestration in the intervillous space is mediated by variant surface antigens (VSAs) selectively expressed in placental malaria (PM) and specific for chondroitin sulfate A (CSA). In Plasmodium falciparum, these VSAPM appear largely synonymous with the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family variant VAR2CSA.

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