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kininogen

Open Access | Intracellular proteolysis of kininogen by malaria parasites promotes release of active kinins

May 10, 2012 - 10:00 -- Patrick Sampao
Author(s): 
Bagnaresi P, de Barros NM, Assis DM, Melo PM, Fonseca RG, Juliano MA, Pesquero JB, Juliano L, Rosenthal PJ, Carmona AK, Gazarini ML
Reference: 
Malaria Journal 2012, 11:156 (7 May 2012)

MalariaWorldIn the present work, it was demonstrated by mass spectrometry analysis that Plasmodium parasites (Plasmodium chabaudi and Plasmodium falciparum) internalize and process plasma kininogen, thereby releasing vasoactive kinins (Lys-BK, BK and des-Arg9-BK) that may mediate haemodynamic alterations during acute malaria.

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