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hrp2 Gene

False-Negative Rapid Diagnostic Tests for Malaria and Deletion of the Histidine-Rich Repeat Region of the hrp2 Gene

February 2, 2012 - 12:25 -- Patrick Sampao
Ousmane A. Koita, Ogobara K. Doumbo, Donald J. Krogstad, et al.
Am J Trop Med Hyg 2012 86:194-198

MalariaWorldThe importance of these observations is likely to increase as malaria control improves, because lower MOIs are associated with false-negative RDTs and false-negative RDTs are more frequent in persons with asymptomatic infections. These findings suggest that the use of HRP2-based RDTs should be reconsidered.

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