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Effects of the anti-malarial compound cryptolepine and its analogues in human lymphocytes and sperm in the Comet assay

October 31, 2011 - 14:37 -- Patrick Sampao
Rajendran C. Gopalan, Esra Emerce, Colin W. Wright, Bensu Karahalil, Ali E. Karakaya, Diana Anderson
Toxicology Letters, Volume 207, Issue 3, 15 December 2011, Pages 322-325

MalariaWorldIn the context of antimalarial drug development, the data suggest that all cryptolepine compounds and in particular 2,7-dibromocryptolepine cause DNA damage and therefore may not be suitable for pre clinical development as antimalarial agents.

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