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BALB/c mice

Induction of pro-inflammatory mediators in Plasmodium berghei infected BALB/c mice breaks blood-brain-barrier and leads to cerebral malaria in an IL-12 dependent manner

August 1, 2011 - 14:54 -- Patrick Sampao
Author(s): 
Kim E. Schmidt, Beatrix Schumak, Sabine Specht, Bettina Dubben, Andreas Limmer, Achim Hoerauf
Reference: 
Microbes and Infection, Volume 13, Issue 10, September 2011, Pages 828-836

We show that ECM- resistant BALB/c mice were driven into interferon gamma- and IL-12-dependent ECM and subsequent death if they received CpG-oligonucleotides after Plasmodium berghei ANKA (PbA) infection.

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