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nitric oxide

Open Access | Nitric Oxide is Involved in the Upregulation of IFN-γ and IL-10 mRNA Expression by CD8+ T Cells During the Blood Stages of P. chabaudi AS Infection in CBA/Ca Mice

November 22, 2011 - 14:20 -- Patrick Sampao
Author(s): 
M Legorreta-Herrera, S Rivas-Contreras, JL Ventura-Gallegos, A Zentella-Dehesa
Reference: 
Int J Biol Sci 2011; 7:1401-1411

MalariaWorldIn addition, we show that CD8+ T cells exhibit increased apoptosis and up regulate the expression of TNF-α mRNA on day 4 post-infection and IFN-γ and IL-10 mRNA on day 11 post-infection.

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Open Access | Study Protocol: Inhaled Nitric Oxide for the Adjunctive Therapy of Severe Malaria: Protocol for a Randomized Controlled Trial

July 20, 2011 - 15:00 -- Patrick Sampao
Author(s): 
Michael Hawkes, Robert O Opoka, Kevin C Kain, et al.
Reference: 
Trials 2011, 12:176

This prospective, parallel arm, randomized, placebo-controlled, blinded clinical trial compares adjunctive continuous inhaled nitric oxide at 80 ppm to placebo (both arms receiving standard anti-malarial therapy), among Ugandan children aged 1-10 years of age with severe malaria.

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