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Prevalence and spectrum of illness among hospitalized adults with malaria in Blantyre, Malawi

November 4, 2014 - 07:13 -- Open Access
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Author(s): 
Dalitso Segula, Anne P Frosch, Miguel SanJoaquin, Dalitso Taulo, Jacek Skarbinski, Don P Mathanga, Theresa J Allain, Malcolm Molyneux, Miriam K Laufer, Robert S Heyderman
Reference: 
Malaria Journal 2014, 13:391 (2 October 2014)

 

In this study of adults admitted to hospital in southern Malawi, an area with year-round transmission of Plasmodium falciparum, classical metabolic and organ complications of malaria were not encountered.

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Not Open Access | Increased Carboxyhemoglobin in Adult Falciparum Malaria is Associated With Disease Severity and Mortality

August 7, 2013 - 18:13 -- NOT Open Access
Author(s): 
Tsin W. Yeo, Daniel A. Lampah, Enny Kenangalem, Emiliana Tjitra, Ric N. Price and Nicholas M. Anstey
Reference: 
J Infect Dis. (2013) 208 (5): 813-817.
MalariaWorld

Increased carboxyhemoglobin levels during severe malaria and sepsis may exacerbate organ dysfunction by reducing oxygen carriage and cautions against the use of adjunctive CO therapy, which was proposed on the basis of mouse models.

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Severe imported falciparum malaria among adults requiring intensive care: a retrospective study at the hospital for tropical diseases, London

March 6, 2013 - 16:25 -- Open Access
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Author(s): 
Marks ME, Armstrong M, Suvari MM, Batson S, Whitty CJ, Chiodini PL, Bellinghan G, Doherty JF
Reference: 
BMC Infectious Diseases 2013, 13:118 (5 March 2013)
MalariaWorld

Retrospective study of patients with WHO severe falciparum malaria admitted to ICU at the Hospital for Tropical Diseases, London, UK. The relationship between clinical variables and risk of death or a prolonged ICU stay were examined with logistic regression.

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Corrigendum to “Physiological adaptation to maternal malaria and other adverse exposure: Low birth weight, functional capacity, and possible metabolic disease in adult life” [Int J Gynecol Obstet 115 (Suppl. 1):S16-S19]

May 1, 2012 - 13:15 -- Patrick Sampao
Author(s): 
Dirk L. Christensen, Anil Kapur, Ib C. Bygbjerg
Reference: 
International Journal of Gynecology & Obstetrics, Volume 117, Issue 3, June 2012, Page 298

No abstract available.

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Open Access | Performance of Two Malaria Rapid Diagnostic Tests in Febrile Adult Patients with and without Human Immunodeficiency Virus-1 Infection in Blantyre, Malawi

February 2, 2012 - 11:52 -- Patrick Sampao
Author(s): 
Jobiba Chinkhumba, Monica Nyanda, Jacek Skarbinski and Don P. Mathanga
Reference: 
Am J Trop Med Hyg 2012 86:199-202

MalariaWorldThe performance of two histidine-rich protein type-2–based malaria rapid diagnostic tests (mRDTs) was examined in a rural area with a high prevalence of malaria and human immunodeficiency virus type-1 (HIV-1) infection in 113 and 445 febrile patients ≥ 15 years of age with and without HIV-1 infection, respectively.

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Open Access | Coma in fatal adult human malaria is not caused by cerebral oedema

September 21, 2011 - 13:28 -- Patrick Sampao
Author(s): 
Isabelle M Medana, Nicholas PJ Day, Navakanit Sachanonta, Nguyen TH Mai, Arjen M Dondorp, Emsri Pongponrat, Tran T Hien, Nicholas J White, Gareth DH Turner
Reference: 
Malaria Journal 2011, 10:267 (17 September 2011)

The presence of oedema, plasma protein leakage and evidence of VEGF signalling were heterogeneous in fatal falciparum malaria and did not correlate with pre-mortem coma.

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Open Access | Brain Swelling and Mannitol Therapy in Adult Cerebral Malaria: A Randomized Trial

August 3, 2011 - 12:55 -- Patrick Sampao
Author(s): 
Sanjib Mohanty, Saroj Kanti Mishra, Arjen M Dondorp, et al.
Reference: 
Clinical Infectious Diseases Volume53, Issue4 Pp. 349-355

A computed tomographic (CT) scan of the cerebrum and lumbar puncture with measurement of cerebrospinal fluid (CSF) pressure were performed on admission for 126 consecutive adult Indian patients with cerebral malaria.

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Adult and child malaria mortality in India: a nationally representative mortality survey

November 23, 2010 - 09:27 -- Patrick Sampao
Author(s): 
The Lancet, Volume 376, Issue 9754, 20 November 2010-26 November 2010, Pages 1768-1774
Reference: 
Neeraj Dhingra., Prabhat Jha., Richard Peto., et al.

We aimed to estimate plausible ranges of malaria mortality in India, the most populous country where the disease remains common.

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Open Access | Invited Speaker Presentation: Retinopathy and microcirculation in adult severe malaria

November 3, 2010 - 13:15 -- Patrick Sampao
Author(s): 
Richard James Maude, Abdullah Abu Sayeed, Arjen M Dondorp et al.
Reference: 
Malaria Journal 2010, 9(Suppl 2):I7 (20 October 2010)

A specific retinopathy has been described in African children with cerebral malaria, but in adults this has not been extensively studied.

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Open Access | Early clinical development of artemether-lumefantrine dispersible tablet: palatability of three flavours and bioavailability in healthy subjects

September 7, 2010 - 14:22 -- Kabogo Ndegwa
Author(s): 
Abdulla S, Amuri B, Kabanywanyi AM, Ubben D, Reynolds C, Pascoe S, Fitoussi S, Yeh C, Nuortti M, Sechaud R, Kaiser G, Lefevre G
Reference: 
Malaria Journal 2010, 9:253 (3 September 2010)

Considering that cherry was the preferred flavour, and that the novel A-L dispersible tablet demonstrated similar pharmacokinetic performances to the tablet administered crushed, a cherry-flavoured A-L dispersible tablet formulation was selected for further development and testing in a large efficacy and safety study in African children with malaria.

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