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Open Access | Low doses of killed parasite in CpG elicit vigorous CD4+ T cell responses against blood-stage malaria in mice

July 19, 2010 - 12:16 -- Kabogo Ndegwa
Author(s): 
A Pinzon-Charry, V McPhun, V Kienzle, C Hirunpetcharat, C Engwerda, J McCarthy, MF Good
Reference: 
J Clin Invest, July 12, 2010

Development of a vaccine that targets blood-stage malaria parasites is imperative if we are to sustainably reduce the morbidity and mortality caused by this infection.

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6-(4′-Aryloxy-phenyl)vinyl-1,2,4-trioxanes: A new series of orally active peroxides effective against multidrug-resistant Plasmodium yoelii in Swiss mice

July 15, 2010 - 09:52 -- Kabogo Ndegwa
Author(s): 
Chandan Singh, Ved Prakash Verma, Niraj Krishna Naikade, Ajit Shankar Singh, Mohammad Hassam, Sunil. K. Puri
Reference: 
Bioorganic & Medicinal Chemistry Letters Volume 20, Issue 15, 1 August 2010, Pages 4459-4463

A new series of 6-(4′-aryloxy-phenyl)vinyl-1,2,4-trioxanes 10a–d, 11a–d, and 12a–d have been synthesized and evaluated for their antimalarial activity against multidrug-resistant Plasmodium yoelii in Swiss mice by oral route.

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Brief report: Divergent Roles of IRAK4-Mediated Innate Immune Responses in Two Experimental Models of Severe Malaria

July 2, 2010 - 13:33 -- Patrick Sampao
Author(s): 
Constance A. M. Finney, Ziyue Lu, Michael Hawkes, Wen-Chen Yeh, W. Conrad Liles, AND Kevin C. Kain
Reference: 
Am J Trop Med Hyg, Jul 2010; 83: 69 - 74.

These results show that IRAK4-mediated innate immune inflammatory responses play critical roles in divergent clinical outcomes in murine malaria models.

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Open Access | VEGF Promotes Malaria-Associated Acute Lung Injury in Mice

May 27, 2010 - 07:46 -- Kabogo Ndegwa
Author(s): 
Sabrina Epiphanio, Marta G. Campos, Ana Pamplona, Daniel Carapau, Ana C. Pena, Ricardo Ataíde, Carla A. A. Monteiro, Nuno Félix, Artur Costa-Silva, Claudio R. F. Marinho, Sérgio Dias, Maria M. Mota
Reference: 
PLoS Pathog 6(5): e1000916.

The spectrum of the clinical presentation and severity of malaria infections is broad, ranging from uncomplicated febrile illness to severe forms of disease such as cerebral malaria (CM), acute lung injury (ALI), acute respiratory distress syndrome (ARDS), pregnancy-associated malaria (PAM) or severe anemia (SA).

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Open Access | Alpha-tocopherol transfer protein disruption confers resistance to malarial infection in mice

April 20, 2010 - 09:25 -- Kabogo Ndegwa
Author(s): 
Herbas MS, Ueta YY, Ichikawa C, Chiba M, Ishibashi K, Shichiri M, Fukumoto S, Yokoyama N, Takeya M, Xuan X, Arai H, Suzuki H
Reference: 
Malaria Journal 2010, 9:101 (19 April 2010)

Various factors impact the severity of malaria, including the nutritional status of the host. Vitamin E, an intra and extracellular anti-oxidant, is one such nutrient whose absence was shown previously to negatively affect Plasmodium development.

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Open Access | Research: Oral Activated Charcoal Prevents Experimental Cerebral Malaria in Mice and in a Randomized Controlled Clinical Trial in Man Did Not Interfere with the Pharmacokinetics of Parenteral Artesunate

April 16, 2010 - 08:07 -- Kabogo Ndegwa
Author(s): 
J. Brian de Souza, Uduak Okomo,Michael Walther, et al.
Reference: 
PLoS ONE 5(4): e9867

If future studies succeed in establishing the efficacy of oAC in human malaria, then the characteristics of being inexpensive, well-tolerated at high doses and requiring no sophisticated storage would make oAC a relevant candidate for adjunct therapy to reduce mortality from severe malaria, or for immediate treatment of suspected severe malaria in a rural setting.

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Immunology: Parasitaemia levels in Plasmodium chabaudi infected-mice modify IFN-gamma and IL-10 expression after a homologous or heterologous challenge

March 11, 2010 - 13:18 -- Patrick Sampao
Author(s): 
M. Aguilar-Medina, R. Ramos-Payan, E. Arambula-Meraz, L. Sanchez-Torres, L. Favila-Castillo.
Reference: 
Parasite Immunology,Volume 32, Issue 4, April 2010, Pages: 267-274

CB6F1 mice infected with the nonlethal Plasmodium chabaudi chabaudi AS suffer parasitaemia levels up to 40% (full parasitaemia, FP) and develop both homologous and heterologous (against the lethal Plasmodium yoelii 17XL) protective immunity.

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Author's correction: Blood Transfusion Alters the Course and Outcome of Plasmodium chabaudi AS Infection in Mice

January 31, 2010 - 13:10 -- Ingeborg van Schayk
Author(s): 
Author(s) name(s)George S. Yap and Mary M. Stevenson
Reference: 
Infect. Immun. 2010;78 884

Volume 62, no. 9, pages 3761-3765, 1994. Page 3761, last line of column 1 and first line of column 2: "(0.7 x 109 to 0.9 x 109 RBC in 1 ml of saline per mouse)" should read "(7.0 x 109 to 9.0 x 109 RBC in 1 ml of saline per mouse)."

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