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Sex Affects the Steady-State Pharmacokinetics of Primaquine but Not Doxycycline in Healthy Subjects

November 10, 2009 - 20:57 -- Ingeborg van Schayk
Vu Quoc Binh, Nguyen Trong Chinh, Nguyen Xuan Thanh, Bui Tri Cuong, Nguyen Ngoc Quang, Bui Dai, Thomas Travers, AND Michael D. Edstein
Am J Trop Med Hyg 2009;81 747-753

The primaquine pharmacokinetic data suggest that women have increased exposure to primaquine, which may put them at increased risk for toxicity when administered the same maintenance dose as men. The similar pharmacokinetics of doxycycline between the two sexes justifies the same maintenance dose.


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