human

Open Access | Dispatch: Plasmodium knowlesi in Human, Indonesian Borneo

Author(s):

Melanie Figtree, Rogan Lee, Lisa Bain, Tom Kennedy, Sonia Mackertich, Merrill Urban, Qin Cheng, and Bernard J. Hudson

Reference:

Emerging Infectious Diseases, Volume 16, Number 4–April 2010

Plasmodium knowlesi is now established as the fifth Plasmodium species to cause malaria in humans.

Person:

human

Country:

Indonesian Borneo

Medical Condition:

Plasmodium knowlesi

Open Access | Understanding Human-Plasmodium falciparum Immune Interactions Uncovers the Immunological Role of Worms

Author(s):

Christian Roussilhon, Philippe Brasseur, Patrice Agnamey, Jean-Louis Pérignon, Pierre Druilhe

Reference:

PLoS ONE 5(2): e9309

We investigated here the hypothesis that the delayed acquisition of immunity to malaria could be related to a worm-induced Th2 drive on antimalarial immune responses.

Person:

human

Medical Condition:

Plasmodium falciparum

worms

immunological

Case report: Successful Sporozoite Challenge Model in Human Volunteers with Plasmodium vivax Strain Derived from Human Donors

Author(s):

Sócrates Herrera, Olga Fernández, María R. Manzano, Bermans Murrain, Juana Vergara, Pedro Blanco, Ricardo Palacios, Juan D. Vélez, Judith E. Epstein, Mario Chen-Mok, Zarifah H. Reed, AND Myriam Arévalo-Herrera

Reference:

Am J Trop Med Hyg 2009;81 740-746

In conclusion, malaria-naive volunteers can be safely and reproducibly infected with bites of 2–10 An. albimanus mosquitoes carrying P. vivax sporozoites. This challenge method is suitable for vaccine and anti-malarial drug testing.

Technology:

Person:

Medical Condition: