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Open Access | Dispatch: Plasmodium knowlesi in Human, Indonesian Borneo

April 1, 2010 - 12:51 -- Patrick Sampao
Author(s): 
Melanie Figtree, Rogan Lee, Lisa Bain, Tom Kennedy, Sonia Mackertich, Merrill Urban, Qin Cheng, and Bernard J. Hudson
Reference: 
Emerging Infectious Diseases, Volume 16, Number 4–April 2010

Plasmodium knowlesi is now established as the fifth Plasmodium species to cause malaria in humans.

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Open Access | Understanding Human-Plasmodium falciparum Immune Interactions Uncovers the Immunological Role of Worms

March 5, 2010 - 16:45 -- Ingeborg van Schayk
Author(s): 
Christian Roussilhon, Philippe Brasseur, Patrice Agnamey, Jean-Louis Pérignon, Pierre Druilhe
Reference: 
PLoS ONE 5(2): e9309

We investigated here the hypothesis that the delayed acquisition of immunity to malaria could be related to a worm-induced Th2 drive on antimalarial immune responses.

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Case report: Successful Sporozoite Challenge Model in Human Volunteers with Plasmodium vivax Strain Derived from Human Donors

November 10, 2009 - 20:48 -- Ingeborg van Schayk
Author(s): 
Sócrates Herrera, Olga Fernández, María R. Manzano, Bermans Murrain, Juana Vergara, Pedro Blanco, Ricardo Palacios, Juan D. Vélez, Judith E. Epstein, Mario Chen-Mok, Zarifah H. Reed, AND Myriam Arévalo-Herrera
Reference: 
Am J Trop Med Hyg 2009;81 740-746

In conclusion, malaria-naive volunteers can be safely and reproducibly infected with bites of 2–10 An. albimanus mosquitoes carrying P. vivax sporozoites. This challenge method is suitable for vaccine and anti-malarial drug testing.

 

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