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Two functional reticulocyte binding-like (RBL) invasion ligands of zoonotic Plasmodium knowlesi exhibit differential adhesion to monkey and human erythrocytes

July 13, 2012 - 10:48 -- Patrick Sampao
Author(s): 
Semenya AA, Tran TM, Meyer EV, Barnwell JW, Galinski MR
Reference: 
Malaria Journal 2012, 11:228 (6 July 2012)

MalariaWorldThe data reported here begins to clarify the functional domains of the P. knowlesi RBLs. A binding domain has been identified and characterized in PkNBPXb. Notably, this study demonstrates that unlike PkNBPXb, PkNBPXa can bind to human erythrocytes, suggesting that PkNBPXa may function as a ligand to enable the invasion of P. knowlesi merozoites into human cells.

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NOT Open Access | Review: Development of humanized mouse models to study human malaria parasite infection

May 11, 2012 - 12:33 -- Patrick Sampao
Author(s): 
Ashley M Vaughan, Stefan HI Kappe, Alexander Ploss & Sebastian A Mikolajczak
Reference: 
Future Microbiology, May 2012, Vol. 7, No. 5, Pages 657-665

MalariaWorldHere, we review the current state of research in this field and provide an outlook of the development of humanized small animal models to study P. falciparum infection that will accelerate fundamental research into human parasite biology and could accelerate drug and vaccine design in the future.

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Review: Defining the protein interaction network of human malaria parasite Plasmodium falciparum

February 2, 2012 - 09:05 -- Patrick Sampao
Author(s): 
Abhinay Ramaprasad, Arnab Pain, Timothy Ravasi
Reference: 
Genomics, Volume 99, Issue 2, February 2012, Pages 69–75

MalariaWorldThis review aims to discuss the computational approaches used till date to construct a malaria protein interaction network and to catalog the functional predictions and biological inferences made from analysis of the PPI network.

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Unraveling the Ubiquitome of the Human Malaria Parasite

November 16, 2011 - 09:26 -- Patrick Sampao
Author(s): 
Nadia Ponts, Anita Saraf, Duk-Won D. Chung, Alona Harris, Jacques Prudhomme, Michael P. Washburn, Laurence Florens and Karine G. Le Roch
Reference: 
Journal of Biological Chemistry, 286, 40320-40330.

MalariaWorldHere, we combined immunofluorescent microscopy, biochemical assays, in silico prediction, and mass spectrometry analysis using the multidimensional protein identification technology, or MudPIT, to describe the P. falciparum ubiquitome.

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Comparing metabolic network models based on genomic and automatically inferred enzyme information from Plasmodium and its human host to define drug targets in silico

December 20, 2010 - 09:48 -- Patrick Sampao
Author(s): 
Segun Fatumo, Kitiporn Plaimas, Ezekiel Adebiyi, Rainer König
Reference: 
Infection, Genetics and Evolution, Volume 11, Issue 1, January 2011, Pages 201-208

Comparing the modeling results with a comprehensive list of known drug targets for P. falciparum, showed that we had the best discovery success with a network model consisting only of enzymes from the parasite alone which coding genes were known.

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Open Access | Oral Presentation: Wild chimpanzees are infected with homologous types of human malaria

November 8, 2010 - 15:02 -- Patrick Sampao
Author(s): 
Marco Kaiser, Dorothy H Bray, Zinta Zommers, Emmanuel Couacy-Hymann, Thomas R Gillespie, Heinz Ellerbrok, Fabian H Leendertz
Reference: 
Malaria Journal 2010, 9(Suppl 2):O21 (20 October 2010)

Recent studies using molecular approaches demonstrated that wild and captive gorillas and captive bonobos and chimpanzees are infected with P. falciparum and that these apes harbor parasites broadly related to P. falciparum.

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Open Access | Invited Speaker Presentation: Origin of the human malaria parasite Plasmodium falciparum in gorillas

November 3, 2010 - 13:07 -- Patrick Sampao
Author(s): 
Weimin L., Yingying L., et al.
Reference: 
Malaria Journal 2010, 9(Suppl 2):I6 (20 October 2010)

Here, we used single genome amplification (SGA) strategies to show that wild-living African apes are naturally infected with at least nine Plasmodium species, including one that is the direct precursor of P.falciparum.

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Open Access | Invited Speaker Presentation: Insights from monkey malaria that can change thinking about human infections

November 3, 2010 - 12:27 -- Patrick Sampao
Author(s): 
Janet Cox-Singh
Reference: 
Malaria Journal 2010, 9(Suppl 2):I2 (20 October 2010)

Despite prolonged and intense effort to understand and control the health impact of malaria morbidity and mortality, malaria remains third in the global ranking for severe and fatal infections.

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Malaria parasite sequences from chimpanzee support the co-speciation hypothesis for the origin of virulent human malaria (Plasmodium falciparum)

September 6, 2010 - 14:30 -- Patrick Sampao
Author(s): 
Austin L. Hughes, Federica Verra
Reference: 
Molecular Phylogenetics and Evolution, Volume 57, Issue 1, October 2010, Pages 135-143

The available data are thus most consistent with the hypothesis that P. reichenowi (in the strict sense) and P. falciparum co-speciated with their hosts about 5–7 million years ago.

Update: Neuropathogenesis of human and murine malaria

May 31, 2010 - 13:43 -- Patrick Sampao
Author(s): 
Eleanor M. Riley, Kevin N. Couper, Helena Helmby, Julius C.R. Hafalla, J. Brian de Souza, Jean Langhorne, W. (Bill) Jarra, Fidel Zavala
Reference: 
Trends in Parasitology, Volume 26, Issue 6, June 2010, Pages 277-278

No abstract available.

 

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